Twins vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 5:19 a.m.

The Minnesota Twins versus the Cleveland Guardians is on the MLB schedule for Friday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Twins vs Guardians Game Info

• Minnesota Twins (66-86) vs. Cleveland Guardians (81-71)
• Date: Friday, September 19, 2025
• Time: 8:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CLEG

Twins vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-118) | CLE: (-100)
• Spread: MIN: +1.5 (-205) | CLE: -1.5 (+168)
• Total: 7.5 -- Over: (-130) | Under: (+106)

Twins vs Guardians Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 5-4, 2.64 ERA vs Parker Messick (Guardians) - 3-0, 1.84 ERA

The probable pitchers are Pablo Lopez (5-4) for the Twins and Parker Messick (3-0) for the Guardians. Lopez and his team are 8-5-0 ATS this season when he starts. Lopez's team has a record of 8-2 this season when he starts and they are the favorite on the moneyline. The Guardians have gone 3-2-0 against the spread when Messick starts. The Guardians have a 1-2 record in Messick's three starts this season when they were the underdog on the moneyline.

Twins vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (66.8%)

Twins vs Guardians Moneyline

• Cleveland is a -100 underdog on the moneyline, while Minnesota is a -118 favorite at home.

Twins vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Twins. The Guardians are +168 to cover, while the Twins are -205 to cover as a 1.5-run underdog on the runline.

Twins vs Guardians Over/Under

• A combined run total of 7.5 has been set for Twins-Guardians on Sept. 19, with the over at -130 and the under at +106.

Bet on Minnesota Twins vs. Cleveland Guardians on FanDuel today!

Twins vs Guardians Betting Trends

• The Twins have been chosen as favorites in 86 games this year and have walked away with the win 40 times (46.5%) in those games.
• Minnesota has a record of 34-33 in contests when bookmakers favor them by -118 or more on the moneyline.
• The Twins' games have gone over the total in 71 of their 147 opportunities.
• In 147 games with a line this season, the Twins have a mark of 71-76-0 against the spread.
• The Guardians have been the underdog on the moneyline 85 total times this season. They've finished 39-46 in those games.
• When playing as a moneyline underdog with odds of -100 or longer, Cleveland has a record of 33-35 (48.5%).
• The Guardians have combined with opponents to hit the over on the total 64 times this season for a 64-79-6 record against the over/under.
• The Guardians have an 81-68-0 record ATS this season.

Twins Player Leaders

• Byron Buxton leads Minnesota with 122 hits and an OBP of .333, plus a team-best slugging percentage of .551. He's batting .270.
• Among qualified hitters, he is 37th in batting average, his on-base percentage ranks 62nd, and he is fifth in slugging.
• Buxton has picked up at least one hit in three games in a row. During his last five outings he is hitting .182 with two doubles and two walks.
• Trevor Larnach has hit 17 homers this season while driving in 60 runs. He's batting .253 this season and slugging .409 with an on-base percentage of .327.
• He ranks 84th in batting average, 76th in on-base percentage and 89th in slugging among qualified hitters.
• Larnach has picked up at least one hit in three games in a row. In his last five games he is hitting .176 with a double, a home run, four walks and three RBIs.
• Brooks Lee has collected 110 base hits, an OBP of .292 and a slugging percentage of .379 this season.
• Lee brings a two-game hitting streak into this game. During his last five outings he is batting .353 with a double, a home run, two walks and five RBIs.
• Kody Clemens has 19 home runs, 50 RBI and a batting average of .213 this season.

Guardians Player Leaders

• Jose Ramirez has accumulated a team-best OBP (.357), while leading the Guardians in hits (157). He's batting .282 and slugging.
• Including all qualifying hitters, he is 21st in batting average, while his on-base percentage ranks 26th and he is 14th in slugging.
• Steven Kwan paces his team with a .373 slugging percentage. He has a batting average of .272 with an on-base percentage of .332.
• His batting average ranks 36th among all qualified players, his on-base percentage ranks 65th, and he is 128th in slugging.
• Kyle Manzardo has 17 doubles, two triples, 26 home runs and 47 walks while batting .240.
• Angel Martinez is hitting .230 with 22 doubles, two triples, 11 home runs and 21 walks.

Twins vs Guardians Head to Head

• 8/3/2025: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/2/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/1/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/21/2025: 5-1 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/1/2025: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/17/2024: 4-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)

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