Diamondbacks vs Phillies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 7:14 a.m.

The MLB slate on Friday includes the Arizona Diamondbacks facing the Philadelphia Phillies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Diamondbacks vs Phillies Game Info

• Arizona Diamondbacks (77-76) vs. Philadelphia Phillies (91-62)
• Date: Friday, September 19, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: MLB Network, ARID, and NBCS-PH

Diamondbacks vs Phillies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-120) | PHI: (+102)
• Spread: ARI: -1.5 (+162) | PHI: +1.5 (-196)
• Total: 9.5 -- Over: (+104) | Under: (-128)

Diamondbacks vs Phillies Probable Starting Pitchers

Probable Pitchers: Ryne Nelson (Diamondbacks) - 7-3, 3.34 ERA vs Taijuan Walker (Phillies) - 5-8, 4.17 ERA

The Diamondbacks will give the ball to Ryne Nelson (7-3, 3.34 ERA), who is eyeing win No. 8 on the season, and the Phillies will counter with Taijuan Walker (5-8, 4.17 ERA). When Nelson starts, his team is 12-9-0 against the spread this season. When Nelson starts a game and his team is the favorite on the moneyline, they have a record of 6-4. The Phillies have gone 10-8-0 against the spread when Walker starts. The Phillies have a 4-2 record in Walker's six starts this season when they were the moneyline underdog.

Diamondbacks vs Phillies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (55%)

Diamondbacks vs Phillies Moneyline

• The moneyline numbers for Diamondbacks vs. Phillies reveal Arizona as the favorite (-120) and Philadelphia as the underdog (+102) on the road.

Diamondbacks vs Phillies Spread

• The Diamondbacks are favored by 1.5 runs at home against the Phillies. The Diamondbacks are +162 to cover the spread, while the Phillies are -196.

Diamondbacks vs Phillies Over/Under

• A combined run total of 9.5 has been set for Diamondbacks-Phillies on Sept. 19, with the over at +104 and the under at -128.

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Diamondbacks vs Phillies Betting Trends

• The Diamondbacks have been victorious in 44, or 53%, of the 83 contests they have been chosen as favorites in this season.
• This year Arizona has won 30 of 61 games when listed as at least -120 on the moneyline.
• The Diamondbacks and their opponents have gone over in 74 of their 149 games with a total set by sportsbooks this season.
• The Diamondbacks are 74-75-0 against the spread in their 149 games that had a posted line this season.
• The Phillies have been the underdog on the moneyline 28 total times this season. They've finished 13-15 in those games.
• In games it has played as a moneyline underdog with odds of +102 or longer, Philadelphia has a record of 10-9 (52.6%).
• The Phillies have had an over/under set by bookmakers 146 times, and have combined with opponents to go over the total in 61 of those games (61-76-9).
• The Phillies have gone 76-70-0 ATS this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has an OPS of .852, fueled by an OBP of .391 to go with a slugging percentage of .461. He has a .289 batting average, as well.
• He is 13th in batting average, fourth in on-base percentage, and 48th in slugging among qualifying hitters in MLB.
• Perdomo will look for his ninth straight game with a hit in this matchup. In his last 10 games he is batting .333 with two doubles, a triple, two home runs, eight walks and six RBIs.
• Corbin Carroll leads Arizona with 139 hits. He is batting .258 this season and has 77 extra-base hits. He's also slugging .545 with an on-base percentage of .339.
• Among all qualifying hitters, he ranks 70th in batting average, 51st in on-base percentage and sixth in slugging percentage.
• Carroll has picked up a hit in four straight games. In his last five games he is batting .333 with a double, a triple, five walks and two RBIs.
• Ketel Marte has collected 123 base hits, an OBP of .372 and a slugging percentage of .497 this season.
• Gabriel Moreno has been key for Arizona with 70 hits, an OBP of .349 plus a slugging percentage of .451.

Phillies Player Leaders

• Kyle Schwarber has accumulated an on-base percentage of .370 and has 138 hits, both team-high marks for the Phillies. He's batting .243 and slugging .567.
• Including all qualifying hitters, he is 102nd in batting average, while his on-base percentage is 12th and he is fourth in slugging.
• Bryce Harper is batting .263 with 32 doubles, 27 home runs and 66 walks. He's slugging .501 with an on-base percentage of .358.
• Including all qualified players, he ranks 54th in batting average, 25th in on-base percentage and 15th in slugging percentage.
• Bryson Stott is hitting .257 with 20 doubles, three triples, 12 home runs and 52 walks.
• Nick Castellanos has 27 doubles, two triples, 16 home runs and 31 walks while hitting .252.

Diamondbacks vs Phillies Head to Head

• 5/4/2025: 11-9 ARI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/3/2025: 7-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/2/2025: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/11/2024: 12-5 ARI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/10/2024: 11-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 3-2 ARI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/8/2024: 6-4 PHI (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/23/2024: 4-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 6/22/2024: 12-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 6/21/2024: 5-4 ARI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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