Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 5:17 a.m.

MLB action on Friday includes the Houston Astros playing the Seattle Mariners.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Mariners Game Info

• Houston Astros (84-69) vs. Seattle Mariners (84-69)
• Date: Friday, September 19, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-112) | SEA: (-104)
• Spread: HOU: +1.5 (-205) | SEA: -1.5 (+168)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 12-7, 2.27 ERA vs Bryan Woo (Mariners) - 14-7, 3.02 ERA

The Astros will look to Hunter Brown (12-7) against the Mariners and Bryan Woo (14-7). Brown and his team are 17-12-0 ATS this season when he starts. Brown's team has a record of 13-9 this season when he starts and they are the favorite on the moneyline. The Mariners have gone 12-17-0 ATS in Woo's 29 starts with a set spread. The Mariners are 3-3 in Woo's six starts this season that they were the underdog on the moneyline.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53%)

Astros vs Mariners Moneyline

• Houston is the favorite, -112 on the moneyline, while Seattle is a -104 underdog on the road.

Astros vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Astros. The Mariners are +168 to cover, while the Astros are -205 to cover as a 1.5-run underdog on the runline.

Astros vs Mariners Over/Under

• An over/under of 7.5 has been set for Astros-Mariners on Sept. 19, with the over being +104 and the under -128.

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Astros vs Mariners Betting Trends

• The Astros have come away with 50 wins in the 94 contests they have been listed as the favorites in this season.
• This season Houston has been victorious 49 times in 93 chances when named as a favorite of at least -112 on the moneyline.
• The Astros' games have gone over the total in 69 of their 152 opportunities.
• The Astros are 77-75-0 against the spread in their 152 games with a line set by sportsbooks this season.
• The Mariners have won 46.2% of the games this season they were the underdog on the moneyline (18-21).
• Seattle has gone 18-18 when it has played as a moneyline underdog with odds of -104 or longer (50%).
• In the 148 games bookmakers have set an over/under for the Mariners, they have combined with opponents to go over the total 80 times (80-63-5).
• The Mariners have put together a 65-83-0 record against the spread this season.

Astros Player Leaders

• Jose Altuve leads Houston in slugging percentage (.444) thanks to 49 extra-base hits. He has a .263 batting average and an on-base percentage of .324.
• Among qualified hitters in MLB, he is 54th in batting average, 82nd in on-base percentage, and 64th in slugging.
• Altuve has picked up at least one hit in two straight games. In his last five games he is batting .313 with two home runs and five RBIs.
• Jeremy Pena leads Houston in OBP (.364), slugging percentage (.474) and total hits (148) this season. He's batting .305.
• He is fourth in batting average, 15th in on-base percentage and 36th in slugging in MLB.
• Pena enters this matchup looking to extend his six-game hit streak. In his last 10 games he is batting .318 with four doubles, a home run, two walks and five RBIs.
• Yainer Diaz has 131 hits this season and has a slash line of .257/.287/.418.
• Diaz heads into this matchup with two games in a row with at least one hit. In his last five games he is hitting .333 with a double and five RBIs.
• Carlos Correa is batting .276 with a .331 OBP and 50 RBI for Houston this season.
• Correa heads into this matchup on a three-game hitting streak. During his last five outings he is batting .316 with two doubles and three walks.

Mariners Player Leaders

• Cal Raleigh has a team-best OBP (.359), while pacing the Mariners in hits (139). He's batting .247 and slugging.
• Including all the qualifying hitters in the big leagues, his batting average ranks 97th, his on-base percentage is 21st, and he is third in slugging.
• Raleigh enters this game on a six-game hitting streak. In his last 10 outings he is batting .314 with three doubles, three home runs, 10 walks and five RBIs.
• Julio Rodriguez's .475 slugging percentage leads his team. He has a batting average of .269 with an on-base percentage of .321.
• Including all qualifying hitters, he is 40th in batting average, 90th in on-base percentage and 33rd in slugging percentage.
• Josh Naylor has 26 doubles, a triple, 19 home runs and 47 walks while hitting .287.
• Eugenio Suarez has 26 doubles, 46 home runs and 44 walks while batting .228.

Astros vs Mariners Head to Head

• 7/20/2025: 11-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/19/2025: 7-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/18/2025: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/25/2025: 5-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/24/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 5-3 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)

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