Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 7:12 a.m.

The Milwaukee Brewers versus the St. Louis Cardinals is on the MLB schedule for Friday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (94-59) vs. St. Louis Cardinals (74-79)
• Date: Friday, September 19, 2025
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSWI

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | STL: (-100)
• Spread: MIL: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 5-2, 4.35 ERA vs Sonny Gray (Cardinals) - 13-8, 4.43 ERA

The probable pitchers are Jacob Misiorowski (5-2) for the Brewers and Sonny Gray (13-8) for the Cardinals. Misiorowski and his team are 8-5-0 ATS this season when he starts. Misiorowski's team is 4-3 this season when he starts and they are the moneyline favorite. The Cardinals have gone 14-14-0 ATS in Gray's 28 starts that had a set spread. The Cardinals are 5-4 in Gray's nine starts this season that they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Brewers, St. Louis is the underdog at -100, and Milwaukee is -118 playing on the road.

Brewers vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Brewers. The Cardinals are -192 to cover, and the Brewers are +158.

Brewers vs Cardinals Over/Under

• The over/under for the Brewers versus Cardinals game on Sept. 19 has been set at 7.5, with -114 odds on the over and -106 odds on the under.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been victorious in 58, or 65.9%, of the 88 contests they have been chosen as favorites in this season.
• This season Milwaukee has come away with a win 53 times in 78 chances when named as a favorite of at least -118 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 76 of their 150 opportunities.
• The Brewers have an against the spread record of 85-65-0 in 150 games with a line this season.
• The Cardinals have won 47.6% of the games this season they were the moneyline underdog (39-43).
• St. Louis has a 27-38 record (winning 41.5% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Cardinals have combined with opponents to hit the over on the total 75 times this season for a 75-67-5 record against the over/under.
• The Cardinals have put together a 73-74-0 record ATS this season (covering 49.7% of the time).

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.440) thanks to 46 extra-base hits. He has a .289 batting average and an on-base percentage of .359.
• Among all qualified hitters, he ranks 13th in batting average, his on-base percentage ranks 21st, and he is 66th in slugging.
• Turang will look for his fifth straight game with a hit in this contest. During his last five outings he is hitting .294 with a double, five walks and an RBI.
• William Contreras is hitting .264 with 27 doubles, 17 home runs and 82 walks. He's slugging .406 with an on-base percentage of .359.
• He is 51st in batting average, 21st in on-base percentage and 92nd in slugging in MLB.
• Christian Yelich has collected 144 base hits, an OBP of .346 and a slugging percentage of .467 this season.
• Jackson Chourio has 141 hits, which is tops among Milwaukee hitters this season, while batting .277 with 58 extra-base hits.

Cardinals Player Leaders

• Alec Burleson has 133 hits with a .461 slugging percentage, both team-best marks for the Cardinals. He's batting .285 and with an on-base percentage of .338.
• Including all qualified hitters, he is 19th in batting average, while his on-base percentage ranks 57th and he is 48th in slugging.
• Burleson enters this matchup on a three-game hitting streak. During his last five outings he is hitting .333 with two doubles, a home run, two walks and three RBIs.
• Brendan Donovan's .348 OBP paces his team. He has a batting average of .281 while slugging .407.
• His batting average is 22nd among all qualified players, his on-base percentage is 39th, and he is 91st in slugging.
• Lars Nootbaar is batting .237 with 23 doubles, a triple, 13 home runs and 59 walks.
• Ivan Herrera is hitting .280 with 13 doubles, 16 home runs and 37 walks.

Brewers vs Cardinals Head to Head

• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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