Red Sox vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 6:13 a.m.

The Boston Red Sox are among the MLB squads playing on Saturday, versus the Arizona Diamondbacks.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Diamondbacks Game Info

• Boston Red Sox (78-64) vs. Arizona Diamondbacks (71-71)
• Date: Saturday, September 6, 2025
• Time: 8:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NESN

Red Sox vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-112) | ARI: (-104)
• Spread: BOS: -1.5 (+150) | ARI: +1.5 (-182)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Red Sox vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 10-2, 3.38 ERA vs Brandon Pfaadt (Diamondbacks) - 12-8, 5.33 ERA

The probable pitchers are Lucas Giolito (10-2) for the Red Sox and Brandon Pfaadt (12-8) for the Diamondbacks. Giolito and his team are 16-6-0 ATS this season when he starts. Giolito's team has been victorious in 81.8% of the games he's started as the moneyline favorite with a record of 9-2. The Diamondbacks have a 17-11-0 record against the spread in Pfaadt's starts. The Diamondbacks have been the moneyline underdog in 13 of Pfaadt's starts this season, and they went 6-7 in those games.

Red Sox vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (53.8%)

Red Sox vs Diamondbacks Moneyline

• Looking at the moneyline for Red Sox-Diamondbacks, Boston is the favorite at -112, and Arizona is -104 playing at home.

Red Sox vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the run line against the Red Sox. The Diamondbacks are -182 to cover, and the Red Sox are +150.

Red Sox vs Diamondbacks Over/Under

• The Red Sox-Diamondbacks game on Sept. 6 has been given an over/under of 8.5 runs. The over is set at -124 and the under at +102.

Bet on Boston Red Sox vs. Arizona Diamondbacks on FanDuel today!

Red Sox vs Diamondbacks Betting Trends

• The Red Sox have been favorites in 89 games this season and have come away with the win 52 times (58.4%) in those contests.
• This year Boston has won 51 of 85 games when listed as at least -112 on the moneyline.
• The Red Sox and their opponents have gone over the total this season in 68 of their 141 opportunities.
• The Red Sox are 76-65-0 against the spread in their 141 games with a line set by sportsbooks this season.
• The Diamondbacks have won 48.2% of the games this season they were the moneyline underdog (27-29).
• Arizona has gone 25-28 in games it has played as a moneyline underdog with odds of -104 or longer (47.2%).
• The Diamondbacks have had an over/under set by bookmakers 138 times, and have combined with opponents to go over the total in 68 of those games (68-64-6).
• The Diamondbacks have a 68-70-0 record ATS this season.

Red Sox Player Leaders

• Jarren Duran leads Boston with 140 hits and an OBP of .336, plus a team-best slugging percentage of .446. He's batting .258.
• Among the qualified batters in the majors, his batting average ranks 81st, his on-base percentage ranks 63rd, and he is 67th in slugging.
• Trevor Story is batting .259 with 24 doubles, 23 home runs and 30 walks. He's slugging .434 with an on-base percentage of .306.
• He is 78th in batting average, 122nd in on-base percentage and 77th in slugging in the major leagues.
• Ceddanne Rafaela is batting .246 with a .420 slugging percentage and 60 RBI this year.
• Alex Bregman has 16 home runs, 56 RBI and a batting average of .284 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has a .452 slugging percentage, which paces the Diamondbacks. He's batting .287 with an on-base percentage of .385.
• He is 18th in batting average, seventh in on-base percentage and 56th in slugging percentage among all qualifying hitters in MLB.
• Corbin Carroll has racked up 129 hits to lead his team. He has a batting average of .259 while slugging .559 with an on-base percentage of .334.
• He ranks 78th in batting average, 66th in on-base percentage and fifth in slugging percentage in the big leagues.
• Ketel Marte has an on-base percentage of .390, a team-high for the Diamondbacks.
• Gabriel Moreno is hitting .274 with 10 doubles, a triple, seven home runs and 17 walks.

Red Sox vs Diamondbacks Head to Head

• 9/5/2025: 10-5 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/25/2024: 7-5 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/24/2024: 4-1 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/23/2024: 12-2 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2023: 4-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 2-1 BOS (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/26/2023: 7-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!