Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 6:13 a.m.

MLB action on Saturday includes the San Diego Padres facing the Colorado Rockies.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Rockies Game Info

• San Diego Padres (76-65) vs. Colorado Rockies (40-101)
• Date: Saturday, September 6, 2025
• Time: 8:10 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: COLR and SDPA

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-190) | COL: (+160)
• Spread: SD: -1.5 (-137) | COL: +1.5 (+114)
• Total: 12 -- Over: (-104) | Under: (-118)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 0-0, 0.00 ERA vs McCade Brown (Rockies) - 0-2, 8.22 ERA

The Padres will give the nod to Randy Vasquez versus the Rockies and McCade Brown (0-2). Vasquez did not appear in a game when his team was the moneyline favorite last season. Brown has started two games with set spreads, and the Rockies went 1-1-0. The Rockies were the underdog on the moneyline for two Brown starts this season -- they lost both.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.8%)

Padres vs Rockies Moneyline

• San Diego is a -190 favorite on the moneyline, while Colorado is a +160 underdog at home.

Padres vs Rockies Spread

• The Rockies are at +1.5 on the runline against the Padres. The Rockies are +114 to cover the spread, and the Padres are -137.

Padres vs Rockies Over/Under

• A combined run total of 12 has been set for Padres-Rockies on Sept. 6, with the over at -104 and the under at -118.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have been favorites in 73 games this season and have come away with the win 43 times (58.9%) in those contests.
• San Diego has a record of 9-5 when favored by -190 or more this year.
• The Padres and their opponents have gone over the total this season in 61 of their 139 opportunities.
• The Padres are 75-64-0 against the spread in their 139 games with a line set by sportsbooks this season.
• The Rockies have gone 36-97 in games they were the underdog on the moneyline (winning 27.1% of those games).
• Colorado is 22-74 (winning only 22.9% of its games) when playing as a moneyline underdog of +160 or longer.
• The Rockies have had an over/under set by oddsmakers 137 times, and have combined with opponents to go over the total in 59 of those games (59-74-4).
• The Rockies have collected a 57-80-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 19 home runs and 82 walks while batting .261. He has an on-base percentage of .367 and a slugging percentage of .429.
• He ranks 71st in batting average, 14th in on-base percentage, and 80th in slugging among qualified hitters in baseball.
• Tatis has recorded at least one hit in two straight games. During his last five outings he is batting .158 with a home run, three walks and an RBI.
• Manny Machado leads San Diego in total hits (153) this season while batting .281 with 54 extra-base hits. He's slugging .461 with an on-base percentage of .342.
• Among qualified hitters, his batting average places him 23rd, his on-base percentage 50th, and his slugging percentage 51st.
• Luis Arraez leads San Diego in slugging percentage (.391) powered by 40 extra-base hits.
• Ramon Laureano is batting .300 with a .361 OBP and 70 RBI for San Diego this season.
• Laureano enters this game on a six-game hitting streak. In his last 10 outings he is hitting .316 with two doubles, three home runs, two walks and nine RBIs.

Rockies Player Leaders

• Hunter Goodman has 132 hits with a .331 on-base percentage and a .538 slugging percentage, all club-highs for the Rockies. He's batting .285.
• Including all the qualifying hitters in the big leagues, he is 20th in batting average, 73rd in on-base percentage and 10th in slugging percentage.
• Goodman heads into this matchup on a three-game hitting streak. In his last five games he is batting .526 with two doubles, two home runs, a walk and 10 RBIs.
• Mickey Moniak is batting .266 with 17 doubles, eight triples, 18 home runs and 20 walks. He's slugging .501 with an on-base percentage of .305.
• Jordan Beck has an on-base percentage of .331, a team-high for the Rockies.
• Brenton Doyle has 19 doubles, two triples, 14 home runs and 29 walks while batting .247.

Padres vs Rockies Head to Head

• 9/5/2025: 3-0 COL (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/11/2025: 9-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/10/2025: 21-0 SD (Favorite: Padres, Spread: -1.5, Total: 12, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/9/2025: 13-9 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 4/13/2025: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/12/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/18/2024: 3-2 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/17/2024: 8-3 SD (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/16/2024: 7-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!