Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 6:13 a.m.

The St. Louis Cardinals are among the MLB teams in action on Saturday, versus the San Francisco Giants.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Cardinals vs Giants Game Info

• St. Louis Cardinals (70-72) vs. San Francisco Giants (72-69)
• Date: Saturday, September 6, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FOX

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | SF: (-102)
• Spread: STL: +1.5 (-192) | SF: -1.5 (+158)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 6-13, 5.37 ERA vs Justin Verlander (Giants) - 3-10, 4.29 ERA

The probable starters are Andre Pallante (6-13) for the Cardinals and Justin Verlander (3-10) for the Giants. Pallante and his team are 13-14-0 ATS this season when he starts. Pallante's team is 4-6 this season when he starts and they are the moneyline favorite. The Giants have a 7-17-0 record against the spread in Verlander's starts. The Giants are 3-8 in Verlander's 11 starts this season that they were the underdog on the moneyline.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.9%)

Cardinals vs Giants Moneyline

• San Francisco is the underdog, -102 on the moneyline, while St. Louis is a -116 favorite at home.

Cardinals vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Cardinals. The Giants are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs Giants Over/Under

• The over/under for Cardinals-Giants on Sept. 6 is 8.5. The over is -104, and the under is -118.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been favorites in 62 games this season and have come away with the win 31 times (50%) in those contests.
• This season St. Louis has been victorious 27 times in 56 chances when named as a favorite of at least -116 on the moneyline.
• The Cardinals and their opponents have gone over in 71 of their 136 games with a total set by sportsbooks this season.
• The Cardinals have posted a record of 69-67-0 against the spread this season.
• The Giants have put together a 26-29 record in games they were listed as the moneyline underdog (winning 47.3% of those games).
• In games it has played as a moneyline underdog with odds of -102 or longer, San Francisco has gone 21-25 (45.7%).
• The Giants have combined with opponents to hit the over on the total 67 times this season for a 67-66-7 record against the over/under.
• The Giants have a 65-75-0 record ATS this season.

Cardinals Player Leaders

• Masyn Winn has 27 doubles, nine home runs and 33 walks while batting .253. He has an on-base percentage of .309 and a slugging percentage of .365.
• Among all qualified hitters in baseball, he is 88th in batting average, 116th in on-base percentage, and 140th in slugging.
• Lars Nootbaar is hitting .240 with 22 doubles, a triple, 13 home runs and 55 walks, while slugging .383 with an on-base percentage of .329.
• Among all qualifying players, he is 118th in batting average, 80th in on-base percentage and 127th in slugging percentage.
• Ivan Herrera has collected 89 base hits, an OBP of .366 and a slugging percentage of .452 this season.
• Victor Scott II has been key for St. Louis with 80 hits, an OBP of .314 plus a slugging percentage of .312.

Giants Player Leaders

• Rafael Devers has accumulated a team-best OBP (.381), and paces the Giants in hits (140). He's batting .264 and slugging.
• Including all qualified hitters in the big leagues, he ranks 62nd in batting average, eighth in on-base percentage and 20th in slugging percentage.
• Devers hopes to build on a five-game hitting streak in this matchup. During his last five outings he is batting .391 with a double, four home runs, two walks and eight RBIs.
• Jung Hoo Lee is batting .267 with 30 doubles, 11 triples, seven home runs and 44 walks. He's slugging .414 with an on-base percentage of .330.
• He is currently 52nd in batting average, 76th in on-base percentage and 92nd in slugging percentage among all qualified hitters.
• Willy Adames is batting .230 with 18 doubles, two triples, 27 home runs and 66 walks.
• Heliot Ramos is slugging .404 to pace his team.

Cardinals vs Giants Head to Head

• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/20/2024: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/14/2023: 8-5 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/13/2023: 11-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/12/2023: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!