Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 4:16 a.m.

Saturday's slate in the MLB includes a matchup between the Tampa Bay Rays and the Cleveland Guardians.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Rays vs Guardians Game Info

• Tampa Bay Rays (71-70) vs. Cleveland Guardians (70-70)
• Date: Saturday, September 6, 2025
• Time: 7:05 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-138) | CLE: (+118)
• Spread: TB: -1.5 (+150) | CLE: +1.5 (-182)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Shane Baz (Rays) - 9-11, 4.98 ERA vs Tanner Bibee (Guardians) - 9-11, 4.77 ERA

The probable starters are Shane Baz (9-11) for the Rays and Tanner Bibee (9-11) for the Guardians. Baz and his team are 12-14-0 ATS this season when he starts. Baz's team has a record of 7-5 this season when he starts and they are the favorite on the moneyline. When Bibee starts, the Guardians have gone 15-11-0 against the spread. The Guardians have a 4-8 record in Bibee's 12 starts this season when they were the underdog on the moneyline.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (65.1%)

Rays vs Guardians Moneyline

• Tampa Bay is the favorite, -138 on the moneyline, while Cleveland is a +118 underdog on the road.

Rays vs Guardians Spread

• The Rays are favored by 1.5 runs at home versus the Guardians. The Rays are +150 to cover the spread, while the Guardians are -182.

Rays vs Guardians Over/Under

• An over/under of 8.5 has been set for Rays-Guardians on Sept. 6, with the over being -105 and the under -115.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have been victorious in 38, or 59.4%, of the 64 contests they have been chosen as favorites in this season.
• This year Tampa Bay has won 19 of 34 games when listed as at least -138 on the moneyline.
• The Rays and their opponents have hit the over in 59 of their 136 games with a total set by oddsmakers this season.
• The Rays have posted a record of 61-75-0 against the spread this season.
• The Guardians have a 34-46 record in games they were the underdog on the moneyline (winning 42.5% of those games).
• When playing as a moneyline underdog with odds of +118 or longer, Cleveland has a record of 18-18 (50%).
• The Guardians have had an over/under set by oddsmakers 137 times, and have combined with opponents to go over the total in 62 of those games (62-69-6).
• The Guardians have a 71-66-0 record ATS this season (covering 51.8% of the time).

Rays Player Leaders

• Junior Caminero has 140 hits, which ranks first among Tampa Bay hitters this season, while batting .263 with 66 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .541.
• Among all qualified batters in baseball, he ranks 63rd in batting average, 125th in on-base percentage, and ninth in slugging.
• Caminero has picked up at least one hit in five games in a row. During his last five outings he is batting .476 with three doubles, two home runs and nine RBIs.
• Yandy Diaz leads the Rays with an OPS of .827. He has a slash line of .293/.352/.475 this season.
• Among qualified batters, his batting average places him 13th, his on-base percentage 39th, and his slugging percentage 34th.
• Brandon Lowe has collected 116 base hits, an OBP of .315 and a slugging percentage of .486 this season.
• Chandler Simpson has no home runs, but 22 RBI and a batting average of .290 this season.

Guardians Player Leaders

• Jose Ramirez has accumulated an on-base percentage of .356 and has 145 hits, both team-high numbers for the Guardians. He's batting .283 and slugging .500.
• Including all qualifying hitters in MLB, he is 22nd in batting average, 31st in on-base percentage and 18th in slugging percentage.
• Steven Kwan paces his team with a .380 slugging percentage. He has a batting average of .274 with an on-base percentage of .331.
• He ranks 37th in batting average, 73rd in on-base percentage and 131st in slugging percentage in the big leagues.
• Kyle Manzardo is hitting .232 with 14 doubles, two triples, 25 home runs and 43 walks.
• Angel Martinez is hitting .225 with 21 doubles, a triple, 10 home runs and 17 walks.

Rays vs Guardians Head to Head

• 9/5/2025: 7-1 CLE (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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