Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 4:14 a.m.

In MLB action on Wednesday, the Detroit Tigers face the Cleveland Guardians.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Guardians Game Info

• Detroit Tigers (85-66) vs. Cleveland Guardians (79-71)
• Date: Wednesday, September 17, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: Fox Sports 1, FDSDET, and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-154) | CLE: (+130)
• Spread: DET: -1.5 (+140) | CLE: +1.5 (-170)
• Total: 8 -- Over: (-110) | Under: (-110)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 8-13, 4.69 ERA vs Gavin Williams (Guardians) - 10-5, 3.16 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (8-13) to the mound, while Gavin Williams (10-5) will answer the bell for the Guardians. Flaherty and his team are 10-18-0 ATS this season when he starts. Flaherty's team has been victorious in 38.9% of the games he's started as the moneyline favorite with a record of 7-11. The Guardians have a 13-16-0 ATS record in Williams' 29 starts with a set spread. The Guardians have an 8-10 record in Williams' 18 starts this season when they were the underdog on the moneyline.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (68.4%)

Tigers vs Guardians Moneyline

• Detroit is the favorite, -154 on the moneyline, while Cleveland is a +130 underdog on the road.

Tigers vs Guardians Spread

• The Tigers are hosting the Guardians and are favored by 1.5 runs on the spread. The Tigers are +140 to cover the runline, with the Guardians being -170.

Tigers vs Guardians Over/Under

• A combined run total of 8 has been set for Tigers-Guardians on Sept. 17, with the over at -110 and the under at -110.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have come away with 58 wins in the 98 contests they have been listed as the favorites in this season.
• This season Detroit has been victorious 34 times in 51 chances when named as a favorite of at least -154 on the moneyline.
• The Tigers and their opponents have hit the over in 75 of their 145 games with a total set by oddsmakers this season.
• The Tigers are 69-76-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Guardians have gone 37-46 in games they were listed as the moneyline underdog (winning 44.6% of those games).
• In games it has played as a moneyline underdog with odds of +130 or longer, Cleveland has a 12-16 record (winning 42.9% of its games).
• The Guardians have played in 147 games with a set over/under, and have combined with opponents to go over the total 64 times (64-77-6).
• The Guardians have a 79-68-0 record against the spread this season (covering 53.7% of the time).

Tigers Player Leaders

• Gleyber Torres leads Detroit with an OBP of .361 this season while batting .254 with 82 walks and 77 runs scored. He has a slugging percentage of .394.
• Among the qualifying hitters in MLB, his batting average ranks 84th, his on-base percentage ranks 17th, and he is 113th in slugging.
• Riley Greene leads Detroit in slugging percentage (.504) and total hits (149) this season. He's batting .265 with an on-base percentage of .319.
• He ranks 47th in batting average, 96th in on-base percentage and 14th in slugging among qualified hitters.
• Spencer Torkelson is batting .242 with a .461 slugging percentage and 74 RBI this year.
• Torkelson enters this matchup with three games in a row with at least one hit. During his last five outings he is batting .368 with a home run, three walks and two RBIs.
• Zach McKinstry has been key for Detroit with 111 hits, an OBP of .336 plus a slugging percentage of .439.

Guardians Player Leaders

• Jose Ramirez has racked up an on-base percentage of .355 and has 155 hits, both team-best marks for the Guardians. He's batting .282 and slugging .500.
• He ranks 21st in batting average, 29th in on-base percentage and 18th in slugging percentage among all qualified hitters in the big leagues.
• Steven Kwan is slugging .377 to lead his team. He has a batting average of .274 with an on-base percentage of .334.
• Including all qualifying hitters, his batting average places him 34th, his on-base percentage ranks 63rd, and he is 128th in slugging.
• Kyle Manzardo is batting .241 with 16 doubles, two triples, 26 home runs and 46 walks.
• Angel Martinez is batting .228 with 22 doubles, two triples, 11 home runs and 19 walks.

Tigers vs Guardians Head to Head

• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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