Pirates vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 5:18 a.m.

In MLB action on Wednesday, the Pittsburgh Pirates take on the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Orioles Game Info

• Pittsburgh Pirates (64-81) vs. Baltimore Orioles (67-77)
• Date: Wednesday, September 10, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SportsNet PT

Pirates vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-148) | BAL: (+126)
• Spread: PIT: -1.5 (+115) | BAL: +1.5 (-138)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Pirates vs Orioles Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 10-9, 1.98 ERA vs Tyler Wells (Orioles) - 1-0, 3.60 ERA

The Pirates will call on Paul Skenes (10-9) versus the Orioles and Tyler Wells (1-0). Skenes' team is 15-14-0 against the spread this season in his starts. Skenes' team has won 61.1% of his starts when they are favored on the moneyline (11-7). Wells has started only one game with a set spread, which the Orioles covered. The Orioles were the moneyline underdog for one Wells start this season -- they won.

Pirates vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (60%)

Pirates vs Orioles Moneyline

• Pittsburgh is a -148 favorite on the moneyline, while Baltimore is a +126 underdog at home.

Pirates vs Orioles Spread

• The Orioles are at +1.5 on the runline against the Pirates. The Orioles are -138 to cover the spread, and the Pirates are +115.

Pirates vs Orioles Over/Under

• The over/under for the Pirates versus Orioles game on Sept. 10 has been set at 7.5, with -105 odds on the over and -115 odds on the under.

Bet on Pittsburgh Pirates vs. Baltimore Orioles on FanDuel today!

Pirates vs Orioles Betting Trends

• The Pirates have been favorites in 36 games this season and have come away with the win 19 times (52.8%) in those contests.
• Pittsburgh has a record of 8-4 in contests when oddsmakers favor them by -148 or more on the moneyline.
• Contests with the Pirates have gone over the total set by bookmakers in 54 of 137 chances this season.
• In 137 games with a line this season, the Pirates have a mark of 75-62-0 against the spread.
• The Orioles have won 46.2% of the games this season they were the underdog on the moneyline (37-43).
• Baltimore is 10-17 (winning just 37% of its games) when playing as a moneyline underdog of +126 or longer.
• The Orioles have played in 141 games with a set over/under, and have combined with their opponents to go over the total 60 times (60-77-4).
• The Orioles have collected a 68-73-0 record against the spread this season (covering 48.2% of the time).

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh in slugging percentage (.408) and total hits (130) this season. He's batting .246 with an on-base percentage of .315.
• Among qualifying hitters in the majors, his batting average ranks 96th, his on-base percentage ranks 104th, and he is 91st in slugging.
• Oneil Cruz is hitting .202 with 17 doubles, two triples, 19 home runs and 61 walks, while slugging .384 with an on-base percentage of .304.
• His batting average is 146th among qualified players, his on-base percentage 121st, and his slugging percentage 121st.
• Andrew McCutchen has 105 hits this season and a team-best OBP of .337.
• McCutchen takes a two-game hitting streak into this game. During his last five outings he is batting .158 with a double, a home run, a walk and two RBIs.
• Tommy Pham is batting .261 with a .335 OBP and 50 RBI for Pittsburgh this season.

Orioles Player Leaders

• Gunnar Henderson has accumulated an on-base percentage of .346, a slugging percentage of .444, and has 139 hits, all club-bests for the Orioles (while batting .272).
• Including all qualifying hitters, he ranks 37th in batting average, while his on-base percentage ranks 44th and he is 65th in slugging.
• Jackson Holliday has 20 doubles, three triples, 17 home runs and 48 walks while hitting .250. He's slugging .395 with an on-base percentage of .318.
• Including all qualified hitters, he ranks 92nd in batting average, 97th in on-base percentage and 110th in slugging percentage.
• Ryan Mountcastle has 18 doubles, five home runs and 14 walks while hitting .259.
• Colton Cowser has 12 doubles, 13 home runs and 19 walks while batting .206.

Pirates vs Orioles Head to Head

• 9/9/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/7/2024: 3-2 PIT (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/6/2024: 5-4 PIT (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/5/2024: 5-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/14/2023: 4-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/13/2023: 2-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/12/2023: 6-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/7/2022: 8-1 PIT (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/6/2022: 6-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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