Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 9:12 a.m.

On Wednesday in MLB, the San Diego Padres are up against the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Reds Game Info

• San Diego Padres (79-66) vs. Cincinnati Reds (73-72)
• Date: Wednesday, September 10, 2025
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-164) | CIN: (+138)
• Spread: SD: -1.5 (+134) | CIN: +1.5 (-162)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 13-5, 2.85 ERA vs Andrew Abbott (Reds) - 8-6, 2.88 ERA

This contest's pitching matchup is set, as the Padres will send Nick Pivetta (13-5) to the mound, while Andrew Abbott (8-6) will answer the bell for the Reds. Pivetta and his team have a record of 16-12-0 against the spread when he starts. Pivetta's team has been victorious in 61.1% of the games he's started as the moneyline favorite with a record of 11-7. The Reds have gone 13-11-0 against the spread when Abbott starts. The Reds are 5-4 in Abbott's nine starts this season that they were the underdog on the moneyline.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.9%)

Padres vs Reds Moneyline

• Looking at the moneyline for Padres-Reds, San Diego is the favorite at -164, and Cincinnati is +138 playing on the road.

Padres vs Reds Spread

• The Padres are hosting the Reds and are favored by 1.5 runs (+134 to cover) on the runline. Cincinnati is -162 to cover.

Padres vs Reds Over/Under

• The Padres-Reds game on Sept. 10 has been given an over/under of 7.5 runs. The over is set at -112 and the under at -108.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have won in 46, or 59.7%, of the 77 contests they have been named as odds-on favorites in this year.
• This season San Diego has been victorious 17 times in 30 chances when named as a favorite of at least -164 on the moneyline.
• The Padres and their opponents have gone over the total this season in 62 of their 143 opportunities.
• The Padres are 77-66-0 against the spread in their 143 games that had a posted line this season.
• The Reds are 37-41 in games they were listed as the moneyline underdog (winning 47.4% of those games).
• When it has played as a moneyline underdog with odds of +138 or longer, Cincinnati has a 9-12 record (winning 42.9% of its games).
• In the 138 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 54 times (54-76-8).
• The Reds have put together a 72-66-0 record against the spread this season (covering 52.2% of the time).

Padres Player Leaders

• Fernando Tatis Jr. is hitting .261 with 27 doubles, two triples, 20 home runs and 84 walks. He has an on-base percentage of .365 and a slugging percentage of .429.
• Among qualifying hitters in the majors, his batting average ranks 70th, his on-base percentage ranks 15th, and he is 78th in slugging.
• Manny Machado has 33 doubles, 23 home runs and 51 walks. He's batting .276 and slugging .458 with an on-base percentage of .337.
• Among qualified hitters, his batting average ranks him 29th, his on-base percentage 54th, and his slugging percentage 50th.
• Luis Arraez leads San Diego in slugging percentage (.386) powered by 40 extra-base hits.
• Ramon Laureano has 23 home runs, 71 RBI and a batting average of .295 this season.

Reds Player Leaders

• Elly De La Cruz has accumulated a team-best slugging percentage (.442) while pacing the Reds in hits (152). He's batting .267 and with an on-base percentage of .335.
• Including all the qualified players in the big leagues, he ranks 48th in batting average, 60th in on-base percentage and 68th in slugging percentage.
• De La Cruz brings a three-game hitting streak into this game. During his last five outings he is batting .200 with a double, a walk and three RBIs.
• TJ Friedl leads his team with a .363 on-base percentage. He has a batting average of .264 while slugging .380.
• He is currently 57th in batting average, 19th in on-base percentage and 126th in slugging percentage among all qualified hitters.
• Spencer Steer has 20 doubles, two triples, 17 home runs and 45 walks while hitting .237.
• Austin Hays is hitting .265 with 15 doubles, five triples, 15 home runs and 27 walks.

Padres vs Reds Head to Head

• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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