Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 9:12 a.m.

The Seattle Mariners will take on the St. Louis Cardinals in MLB action on Wednesday.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Cardinals Game Info

• Seattle Mariners (77-68) vs. St. Louis Cardinals (72-74)
• Date: Wednesday, September 10, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-225) | STL: (+188)
• Spread: SEA: -1.5 (-104) | STL: +1.5 (-115)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 4-6, 3.61 ERA vs Michael McGreevy (Cardinals) - 6-3, 4.68 ERA

The probable pitchers are Logan Gilbert (4-6) for the Mariners and Michael McGreevy (6-3) for the Cardinals. Gilbert's team is 6-14-0 against the spread in his starts this season. Gilbert's team has been victorious in 68.8% of the games he's started as the moneyline favorite with a record of 11-5. The Cardinals are 7-5-0 against the spread when McGreevy starts. The Cardinals have been the moneyline underdog in six of McGreevy's starts this season, and they went 5-1 in those matchups.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (65%)

Mariners vs Cardinals Moneyline

• Looking at the moneyline for Mariners-Cardinals, Seattle is the favorite at -225, and St. Louis is +188 playing on the road.

Mariners vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Mariners. The Cardinals are -115 to cover, and the Mariners are -104.

Mariners vs Cardinals Over/Under

• A combined run total of 7.5 has been set for Mariners-Cardinals on Sept. 10, with the over at -102 and the under at -120.

Bet on Seattle Mariners vs. St. Louis Cardinals on FanDuel today!

Mariners vs Cardinals Betting Trends

• The Mariners have come away with 55 wins in the 98 contests they have been listed as the favorites in this season.
• Seattle has a record of 4-1 when favored by -225 or more this year.
• The Mariners' games have gone over the total in 75 of their 140 opportunities.
• The Mariners have an against the spread record of 60-80-0 in 140 games with a line this season.
• The Cardinals have been the underdog on the moneyline 76 total times this season. They've gone 37-39 in those games.
• St. Louis has played as a moneyline underdog of +188 or longer in only one game this season, which it lost.
• In the 140 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 72 times (72-63-5).
• The Cardinals have gone 70-70-0 ATS this season.

Mariners Player Leaders

• Cal Raleigh leads Seattle in total hits (128) this season while batting .240 with 72 extra-base hits. He has an on-base percentage of .349 and a slugging percentage of .574.
• Among all qualified hitters, he ranks 113th in batting average, his on-base percentage ranks 39th, and he is third in slugging.
• Julio Rodriguez leads Seattle in slugging percentage (.476) thanks to 60 extra-base hits. He's batting .266 with an on-base percentage of .317.
• Among qualified hitters, he ranks 51st in batting average, 100th in on-base percentage and 33rd in slugging percentage.
• Josh Naylor is batting .286 with a .458 slugging percentage and 80 RBI this year.
• Naylor has logged a hit or more in four games in a row. In his last five games he is batting .467 with a double, three home runs, a walk and seven RBIs.
• Eugenio Suarez has 45 home runs, 109 RBI and a batting average of .235 this season.

Cardinals Player Leaders

• Alec Burleson has 125 hits with a .457 slugging percentage, both team-high statistics for the Cardinals. He's batting .285 and with an on-base percentage of .335.
• Including all the qualifying hitters in the big leagues, his batting average ranks 19th, his on-base percentage ranks 60th, and he is 54th in slugging.
• Willson Contreras has 30 doubles, a triple, 20 home runs and 42 walks while batting .256. He's slugging .449 with an on-base percentage of .339.
• His batting average ranks 81st among all qualified players, his on-base percentage ranks 52nd, and he is 62nd in slugging.
• Masyn Winn is hitting .253 with 27 doubles, nine home runs and 34 walks.
• Lars Nootbaar is batting .241 with 22 doubles, a triple, 13 home runs and 56 walks.

Mariners vs Cardinals Head to Head

• 9/9/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/8/2025: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 9/8/2024: 10-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/7/2024: 2-0 STL (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/6/2024: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/23/2023: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/22/2023: 5-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/21/2023: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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