Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 9:12 a.m.

The MLB's Monday slate includes the San Diego Padres facing the Cincinnati Reds.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Reds Game Info

• San Diego Padres (78-65) vs. Cincinnati Reds (72-71)
• Date: Monday, September 8, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-144) | CIN: (+122)
• Spread: SD: -1.5 (+146) | CIN: +1.5 (-178)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 3-5, 5.75 ERA vs Nick Lodolo (Reds) - 8-7, 3.22 ERA

The Padres will give the nod to Yu Darvish (3-5, 5.75 ERA), who is eyeing win No. 4 on the season, and the Reds will counter with Nick Lodolo (8-7, 3.22 ERA). Darvish and his team have a record of 7-3-0 against the spread when he starts. When Darvish starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Reds have a 12-10-0 record against the spread in Lodolo's starts. The Reds have been the underdog on the moneyline in 12 of Lodolo's starts this season, and they went 5-7 in those games.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.3%)

Padres vs Reds Moneyline

• Looking at the moneyline for Reds-Padres, Cincinnati is the underdog at +122, and San Diego is -144 playing at home.

Padres vs Reds Spread

• The Reds are at +1.5 on the runline against the Padres. The Reds are -178 to cover the spread, and the Padres are +146.

Padres vs Reds Over/Under

• A total of 7.5 runs has been set for the Padres-Reds game on Sept. 8, with the over available at -118 and the under at -104.

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Padres vs Reds Betting Trends

• The Padres have been chosen as favorites in 75 games this year and have walked away with the win 45 times (60%) in those games.
• This year San Diego has won 27 of 45 games when listed as at least -144 on the moneyline.
• The Padres and their opponents have gone over the total this season in 62 of their 141 opportunities.
• In 141 games with a line this season, the Padres have a mark of 77-64-0 against the spread.
• The Reds have been the underdog on the moneyline 76 total times this season. They've gone 36-40 in those games.
• When playing as a moneyline underdog with odds of +122 or longer, Cincinnati has a 14-18 record (winning 43.8% of its games).
• The Reds have played in 136 games with a set over/under, and have combined with their opponents to go over the total 54 times (54-74-8).
• The Reds have a 70-66-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .262 with 27 doubles, two triples, 20 home runs and 83 walks. He has an on-base percentage of .367 while slugging .433.
• Among qualifying hitters in MLB, he ranks 70th in batting average, 15th in on-base percentage, and 78th in slugging.
• Tatis hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .227 with two home runs, two walks and four RBIs.
• Manny Machado has 155 hits, which ranks first among San Diego batters this season. He's batting .280 with 56 extra-base hits. He's also slugging .465 with an on-base percentage of .342.
• Among qualified hitters, he is 24th in batting average, 50th in on-base percentage and 46th in slugging percentage.
• Luis Arraez has an OPS of .710, fueled by an OBP of .320 and a team-best slugging percentage of .389 this season.
• Ramon Laureano is batting .300 with a .360 OBP and 71 RBI for San Diego this season.
• Laureano heads into this game on an eight-game hitting streak. During his last 10 games he is hitting .300 with two doubles, two home runs, two walks and five RBIs.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .445 and has 150 hits, both team-high marks for the Reds. He's batting .267 and with an on-base percentage of .336.
• Including all qualified players in the majors, his batting average places him 48th, his on-base percentage is 63rd, and he is 68th in slugging.
• TJ Friedl's .366 on-base percentage paces his team. He has a batting average of .265 while slugging .376.
• He ranks 57th in batting average, 17th in on-base percentage and 132nd in slugging percentage in the big leagues.
• Spencer Steer has 20 doubles, two triples, 17 home runs and 45 walks while hitting .239.
• Austin Hays is batting .263 with 15 doubles, five triples, 14 home runs and 27 walks.

Padres vs Reds Head to Head

• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2024: 5-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/2/2023: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 11, Favorite Moneyline: -132, Underdog Moneyline: +112)

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