Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 9:12 a.m.

Monday's slate in the MLB includes a matchup between the Seattle Mariners and the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Cardinals Game Info

• Seattle Mariners (75-68) vs. St. Louis Cardinals (72-72)
• Date: Monday, September 8, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-225) | STL: (+188)
• Spread: SEA: -1.5 (-102) | STL: +1.5 (-118)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Bryan Woo (Mariners) - 12-7, 3.02 ERA vs Miles Mikolas (Cardinals) - 7-10, 4.89 ERA

The Mariners will look to Bryan Woo (12-7) versus the Cardinals and Miles Mikolas (7-10). When Woo starts, his team is 10-17-0 against the spread this season. Woo's team has won 52.4% of his starts when they are favored on the moneyline (11-10). The Cardinals are 12-15-0 against the spread when Mikolas starts. The Cardinals have an 8-11 record in Mikolas' 19 starts this season when they were the moneyline underdog.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (66.5%)

Mariners vs Cardinals Moneyline

• The Mariners vs Cardinals moneyline has Seattle as a -225 favorite, while St. Louis is a +188 underdog on the road.

Mariners vs Cardinals Spread

• The Mariners are favored by 1.5 runs at home versus the Cardinals. The Mariners are -102 to cover the spread, while the Cardinals are -118.

Mariners vs Cardinals Over/Under

• The over/under for the Mariners versus Cardinals game on Sept. 8 has been set at 7.5, with -112 odds on the over and -108 odds on the under.

Bet on Seattle Mariners vs. St. Louis Cardinals on FanDuel today!

Mariners vs Cardinals Betting Trends

• The Mariners have come away with 53 wins in the 96 contests they have been listed as the favorites in this season.
• Seattle has a record of 3-1 when favored by -225 or more this year.
• The Mariners' games have gone over the total in 74 of their 138 opportunities.
• In 138 games with a line this season, the Mariners have a mark of 58-80-0 against the spread.
• The Cardinals have compiled a 37-37 record in games they were listed as the moneyline underdog (winning 50% of those games).
• St. Louis has yet to play a game with moneyline odds of +188 or longer.
• The Cardinals have played in 138 games with a set over/under, and have combined with their opponents to go over the total 71 times (71-62-5).
• The Cardinals have a 70-68-0 record against the spread this season (covering 50.7% of the time).

Mariners Player Leaders

• Cal Raleigh leads Seattle in total hits (128) this season while batting .243 with 72 extra-base hits. He has an on-base percentage of .351 and a slugging percentage of .581.
• He ranks 109th in batting average, 38th in on-base percentage, and third in slugging among all qualified batters in MLB.
• Raleigh will look for his seventh straight game with a hit in this matchup. In his last 10 outings he is batting .211 with three home runs, six walks and six RBIs.
• Julio Rodriguez has hit 30 homers this season while driving in 89 runs. He's batting .267 this season and slugging .479 with an on-base percentage of .318.
• His batting average is 48th among qualified players, his on-base percentage 99th, and his slugging percentage 32nd.
• Rodriguez has picked up a hit in two games in a row. During his last five outings he is hitting .333 with two doubles, four home runs and 11 RBIs.
• Josh Naylor has 136 hits this season and has a slash line of .282/.345/.448.
• Naylor heads into this matchup with two games in a row with at least one hit. During his last five outings he is batting .250 with two home runs, a walk and four RBIs.
• Eugenio Suarez is batting .238 with a .309 OBP and 109 RBI for Seattle this season.
• Suarez enters this game on a two-game hitting streak. During his last five outings he is batting .238 with three home runs, two walks and four RBIs.

Cardinals Player Leaders

• Masyn Winn has put up a slugging percentage of .365, a team-high for the Cardinals. He's batting .254 with an on-base percentage of .312.
• He is 87th in batting average, 111th in on-base percentage and 139th in slugging percentage among all qualified hitters in MLB.
• Lars Nootbaar is batting .241 with 22 doubles, a triple, 13 home runs and 55 walks. He's slugging .381 with an on-base percentage of .328.
• His batting average ranks 118th among all qualified players, his on-base percentage ranks 78th, and he is 128th in slugging.
• Ivan Herrera is hitting .283 with 12 doubles, 14 home runs and 34 walks.
• Victor Scott II is hitting .226 with 14 doubles, a triple, five home runs and 38 walks.

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