Padres vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 9:12 p.m.

Tuesday's slate in the MLB includes a matchup between the San Diego Padres and the Baltimore Orioles.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Orioles Game Info

• San Diego Padres (76-62) vs. Baltimore Orioles (62-76)
• Date: Tuesday, September 2, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-174) | BAL: (+146)
• Spread: SD: -1.5 (+116) | BAL: +1.5 (-142)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Padres vs Orioles Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 3-4, 5.66 ERA vs Tyler Wells (Orioles) - 0-0, 0.00 ERA

The Padres will give the ball to Yu Darvish (3-4, 5.66 ERA), who is eyeing win No. 4 on the season, and the Orioles will counter with Tyler Wells. Darvish and his team have a record of 7-2-0 against the spread when he starts. Darvish's team has won 66.7% of his starts when they are favored on the moneyline (2-1). Last season Wells' team did not cover in any of his three games pitched with a spread. Wells' team was the underdog on the moneyline only one time in a game he pitched a season ago, and lost.

Padres vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (61.5%)

Padres vs Orioles Moneyline

• Baltimore is a +146 underdog on the moneyline, while San Diego is a -174 favorite at home.

Padres vs Orioles Spread

• The Padres are favored by 1.5 runs at home versus the Orioles. The Padres are +116 to cover the spread, while the Orioles are -142.

Padres vs Orioles Over/Under

• The over/under for the Padres versus Orioles contest on Sept. 2 has been set at 8.5, with -104 odds on the over and -118 odds on the under.

Bet on San Diego Padres vs. Baltimore Orioles on FanDuel today!

Padres vs Orioles Betting Trends

• The Padres have been favorites in 70 games this season and have come away with the win 43 times (61.4%) in those contests.
• San Diego has a record of 13-5 in contests when bookmakers favor them by -174 or more on the moneyline.
• The Padres and their opponents have gone over in 60 of their 136 games with a total set by sportsbooks this season.
• The Padres are 75-61-0 against the spread in their 136 games that had a posted line this season.
• The Orioles have gone 33-42 in games they were listed as the moneyline underdog (winning 44% of those games).
• Baltimore is 5-7 (winning 41.7% of its games) when it has played as a moneyline underdog of +146 or longer.
• The Orioles have played in 135 games with an over/under set, and have combined with their opponents to go over the total 59 times (59-72-4).
• The Orioles have put together a 64-71-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .264 with 27 doubles, two triples, 18 home runs and 81 walks. He has an on-base percentage of .370 while slugging .430.
• Among qualifying hitters in MLB, he is 60th in batting average, 14th in on-base percentage, and 78th in slugging.
• Manny Machado leads San Diego with 151 hits. He is batting .284 this season and has 53 extra-base hits. He's also slugging .462 with an on-base percentage of .346.
• Among qualified batters, he is 22nd in batting average, 45th in on-base percentage and 50th in slugging percentage.
• Luis Arraez leads San Diego in slugging percentage (.388) powered by 39 extra-base hits.
• Arraez enters this matchup with four games in a row with at least one hit. During his last five outings he is batting .353 with a walk and two RBIs.
• Ramon Laureano is batting .293 with a .354 OBP and 70 RBI for San Diego this season.
• Laureano has safely hit in three games in a row. During his last five outings he is hitting .190 with a home run and four RBIs.

Orioles Player Leaders

• Gunnar Henderson has racked up an on-base percentage of .349, a slugging percentage of .457, and has 138 hits, all club-bests for the Orioles (while batting .279).
• Including all qualified players, he ranks 27th in batting average, while his on-base percentage is 42nd and he is 56th in slugging.
• Henderson heads into this game on a four-game hitting streak. During his last five outings he is batting .300 with a walk and two RBIs.
• Jackson Holliday has 20 doubles, three triples, 15 home runs and 44 walks while batting .245. He's slugging .384 with an on-base percentage of .312.
• He is currently 109th in batting average, 112th in on-base percentage and 124th in slugging percentage among all qualified hitters.
• Ryan Mountcastle is batting .264 with 17 doubles, five home runs and 12 walks.
• Colton Cowser is batting .210 with 12 doubles, 12 home runs and 17 walks.

Padres vs Orioles Head to Head

• 9/1/2025: 4-3 BAL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 7/28/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/27/2024: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/26/2024: 6-4 SD (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/16/2023: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2023: 10-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/14/2023: 4-1 BAL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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