Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 7:13 p.m.

In MLB action on Thursday, the Tampa Bay Rays take on the Cleveland Guardians.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Rays vs Guardians Game Info

• Tampa Bay Rays (70-69) vs. Cleveland Guardians (69-69)
• Date: Thursday, September 4, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-166) | CLE: (+140)
• Spread: TB: -1.5 (+118) | CLE: +1.5 (-142)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Ryan Pepiot (Rays) - 10-10, 3.70 ERA vs Logan Allen (Guardians) - 7-10, 4.42 ERA

The Rays will look to Ryan Pepiot (10-10) versus the Guardians and Logan Allen (7-10). When Pepiot starts, his team is 9-18-0 against the spread this season. Pepiot's team has been victorious in 61.5% of the games he's started as the moneyline favorite with a record of 8-5. The Guardians have a 12-12-0 record against the spread in Allen's starts. The Guardians have been the underdog on the moneyline in 15 of Allen's starts this season, and they went 6-9 in those games.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (63.7%)

Rays vs Guardians Moneyline

• The Rays vs Guardians moneyline has Tampa Bay as a -166 favorite, while Cleveland is a +140 underdog on the road.

Rays vs Guardians Spread

• The Rays are favored by 1.5 runs at home versus the Guardians. The Rays are +118 to cover the spread, while the Guardians are -142.

Rays vs Guardians Over/Under

• Rays versus Guardians on Sept. 4 has an over/under of 8.5 runs, with the odds on the over -105 and the under set at -115.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have been victorious in 37, or 59.7%, of the 62 contests they have been chosen as favorites in this season.
• Tampa Bay has a record of 5-8 in contests when sportsbooks favor them by -166 or more on the moneyline.
• The Rays' games have gone over the total in 58 of their 134 opportunities.
• In 134 games with a line this season, the Rays have a mark of 60-74-0 against the spread.
• The Guardians are 33-45 in games they were listed as the moneyline underdog (winning 42.3% of those games).
• Cleveland has a 7-14 record (winning just 33.3% of its games) when it has played as a moneyline underdog of +140 or longer.
• The Guardians have played in 135 games with an over/under set, and have combined with opponents to go over the total 61 times (61-68-6).
• The Guardians have collected a 70-65-0 record ATS this season (covering 51.9% of the time).

Rays Player Leaders

• Junior Caminero has 138 hits, which is best among Tampa Bay hitters this season, while batting .263 with 65 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .540.
• Among qualifying hitters in baseball, he is 66th in batting average, 126th in on-base percentage, and ninth in slugging.
• Caminero has hit safely in three games in a row. During his last five outings he is batting .400 with three doubles, a home run, a walk and eight RBIs.
• Yandy Diaz has a slash line of .294/.353/.479 this season and a team-best OPS of .832.
• Among all qualifying hitters, he ranks 12th in batting average, 36th in on-base percentage and 37th in slugging percentage.
• Diaz has picked up at least one hit in three straight games. In his last five games he is hitting .500 with two doubles, three walks and two RBIs.
• Brandon Lowe has collected 115 base hits, an OBP of .319 and a slugging percentage of .493 this season.
• Lowe enters this game with seven games in a row with at least one hit. During his last 10 outings he is batting .229 with two doubles, three home runs, five walks and 11 RBIs.
• Chandler Simpson has been key for Tampa Bay with 99 hits, an OBP of .328 plus a slugging percentage of .344.
• Simpson has safely hit in three straight games. In his last five games he is batting .273 with .

Guardians Player Leaders

• Jose Ramirez has racked up a team-high OBP (.353), while pacing the Guardians in hits (140). He's batting .278 and slugging.
• Including all qualified hitters in MLB, he is 29th in batting average, 36th in on-base percentage and 28th in slugging percentage.
• Steven Kwan leads his team with a .382 slugging percentage. He has a batting average of .274 with an on-base percentage of .330.
• Including all qualifying players, his batting average places him 37th, his on-base percentage ranks 78th, and he is 128th in slugging.
• Kyle Manzardo is batting .231 with 14 doubles, two triples, 24 home runs and 42 walks.
• Angel Martinez is hitting .226 with 21 doubles, a triple, 10 home runs and 17 walks.

Rays vs Guardians Head to Head

• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/13/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/12/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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