Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 6:12 a.m.

The MLB's Thursday slate includes the Tampa Bay Rays facing the Cleveland Guardians.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Rays vs Guardians Game Info

• Tampa Bay Rays (70-69) vs. Cleveland Guardians (69-69)
• Date: Thursday, September 4, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-144) | CLE: (+122)
• Spread: TB: -1.5 (+130) | CLE: +1.5 (-156)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Ryan Pepiot (Rays) - 10-10, 3.70 ERA vs Logan Allen (Guardians) - 7-10, 4.42 ERA

The Rays will give the ball to Ryan Pepiot (10-10, 3.70 ERA), who is eyeing win No. 11 on the season, and the Guardians will counter with Logan Allen (7-10, 4.42 ERA). Pepiot's team is 9-18-0 against the spread in his starts this season. Pepiot's team has won 61.5% of his starts when they are favored on the moneyline (8-5). The Guardians are 12-12-0 ATS in Allen's 24 starts that had a set spread. The Guardians have been the underdog on the moneyline in 15 of Allen's starts this season, and they went 6-9 in those matchups.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (62.1%)

Rays vs Guardians Moneyline

• Tampa Bay is a -144 favorite on the moneyline, while Cleveland is a +122 underdog on the road.

Rays vs Guardians Spread

• The Rays are hosting the Guardians and are favored by 1.5 runs on the spread. The Rays are +130 to cover the runline, with the Guardians being -156.

Rays vs Guardians Over/Under

• The Rays-Guardians game on Sept. 4 has been given an over/under of 8.5 runs. The over is set at -122 and the under at -100.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have been favorites in 62 games this season and have come away with the win 37 times (59.7%) in those contests.
• Tampa Bay has a record of 9-12 when favored by -144 or more this year.
• The Rays and their opponents have gone over in 58 of their 134 games with a total set by sportsbooks this season.
• In 134 games with a line this season, the Rays have a mark of 60-74-0 against the spread.
• The Guardians have been the moneyline underdog 78 total times this season. They've gone 33-45 in those games.
• Cleveland has a record of 16-15 in games it has played as a moneyline underdog with odds of +122 or longer (51.6%).
• The Guardians have played in 135 games with a set over/under, and have combined with opponents to go over the total 61 times (61-68-6).
• The Guardians have collected a 70-65-0 record ATS this season.

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 138 hits, batting .263 this season with 65 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .540.
• Among the qualified batters in MLB, his batting average ranks 66th, his on-base percentage ranks 126th, and he is ninth in slugging.
• Caminero will look for his fourth straight game with a hit in this matchup. During his last five outings he is hitting .400 with three doubles, a home run, a walk and eight RBIs.
• Yandy Diaz is slashing .294/.353/.479 this season and leads the Rays with an OPS of .832.
• Among qualifying hitters, he is 12th in batting average, 36th in on-base percentage and 37th in slugging percentage.
• Diaz has picked up a hit in three games in a row. During his last five outings he is batting .500 with two doubles, three walks and two RBIs.
• Brandon Lowe is batting .265 with a .493 slugging percentage and 74 RBI this year.
• Lowe takes a seven-game hitting streak into this game. During his last 10 games he is batting .229 with two doubles, three home runs, five walks and 11 RBIs.
• Chandler Simpson has been key for Tampa Bay with 99 hits, an OBP of .328 plus a slugging percentage of .344.
• Simpson brings a three-game hitting streak into this game. In his last five games he is batting .273 with .

Guardians Player Leaders

• Jose Ramirez has put up a team-high OBP (.353), while pacing the Guardians in hits (140). He's batting .278 and slugging.
• Including all the qualifying hitters in MLB, his batting average ranks 29th, his on-base percentage is 36th, and he is 28th in slugging.
• Steven Kwan's .382 slugging percentage leads his team. He has a batting average of .274 with an on-base percentage of .330.
• His batting average is 37th among all qualified players, his on-base percentage ranks 78th, and he is 128th in slugging.
• Kyle Manzardo has 14 doubles, two triples, 24 home runs and 42 walks while batting .231.
• Angel Martinez is batting .226 with 21 doubles, a triple, 10 home runs and 17 walks.

Rays vs Guardians Head to Head

• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/13/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/12/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!