Louisville vs James Madison Prediction, Odds, Picks, Best Bets for Week 2 2025

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The Louisville Cardinals are among the college football squads playing on Friday, versus the James Madison Dukes.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Louisville vs James Madison Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisville: (-581) | James Madison: (+420)
Spread: Louisville: -13.5 (-105) | James Madison: +13.5 (-115)
Total: 55.5 -- Over: (-106) | Under: (-114)

Louisville is winless against the spread this year.
Louisville has yet to win ATS (0-1) when playing as at least 13.5-point favorites this year.
Every Louisville game has gone over the point total this year.
James Madison hasn't lost a game against the spread this year.
James Madison and its opponent have yet to not hit the over this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (81.5%)

James Madison is listed as an underdog by 13.5 points (-115 odds), and Louisville, the favorite, is -105 to cover.

Louisville versus James Madison, on Sept. 5, has an over/under of 55.5, with the over being -106 and the under -114.

Looking at the moneyline for James Madison-Louisville, James Madison is the underdog at +420, and Louisville is -581.

The Cardinals' average implied point total last season was 2.6 fewer points than their implied total in Friday's game (32.4 implied points on average compared to 35 implied points in this game).
The average implied point total last season for the Dukes (33.3) is 12.3 more points than the team's implied total in this matchup (21).

Check out even more in-depth Louisville vs. James Madison analysis on FanDuel Research.

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