Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 6:12 a.m.

The MLB slate on Wednesday includes the Kansas City Royals taking on the Cleveland Guardians.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Royals vs Guardians Game Info

• Kansas City Royals (73-72) vs. Cleveland Guardians (74-70)
• Date: Wednesday, September 10, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSKC

Royals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-110) | CLE: (-106)
• Spread: KC: -1.5 (+155) | CLE: +1.5 (-188)
• Total: 8 -- Over: (-114) | Under: (-106)

Royals vs Guardians Probable Starting Pitchers

Probable Pitchers: Jonathan Bowlan (Royals) - 1-2, 3.57 ERA vs Logan Allen (Guardians) - 7-11, 4.46 ERA

This contest's pitching matchup is set, as the Royals will send Jonathan Bowlan (1-2) to the mound, while Logan Allen (7-11) will get the nod for the Guardians. Bowlan pitched in one game with a spread last season and his team covered. Bowlan did not pitch as the moneyline favorite in any games last season. The Guardians have a 12-13-0 ATS record in Allen's 25 starts that had a set spread. The Guardians have a 6-10 record in Allen's 16 starts this season when they were the underdog on the moneyline.

Royals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (54.2%)

Royals vs Guardians Moneyline

• Kansas City is a -110 favorite on the moneyline, while Cleveland is a -106 underdog at home.

Royals vs Guardians Spread

• The Guardians are +1.5 on the spread (-188 to cover), and Kansas City is +155 to cover the runline.

Royals vs Guardians Over/Under

• Royals versus Guardians, on Sept. 10, has an over/under of 8, with the over being -114 and the under -106.

Bet on Kansas City Royals vs. Cleveland Guardians on FanDuel today!

Royals vs Guardians Betting Trends

• The Royals have been favorites in 62 games this season and have come away with the win 35 times (56.5%) in those contests.
• This year Kansas City has won 35 of 62 games when listed as at least -110 on the moneyline.
• The Royals and their opponents have hit the over in 60 of their 143 games with a total set by oddsmakers this season.
• The Royals are 70-73-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Guardians have been the moneyline underdog 82 total times this season. They've finished 36-46 in those games.
• In games it has played as a moneyline underdog with odds of -106 or longer, Cleveland has a 35-45 record (winning 43.8% of its games).
• The Guardians have played in 141 games with a set over/under, and have combined with their opponents to go over the total 63 times (63-72-6).
• The Guardians are 75-66-0 against the spread this season.

Royals Player Leaders

• Bobby Witt Jr. has 161 hits to go with a slugging percentage of .501, both of which lead Kansas City hitters this season. He has a .293 batting average and an on-base percentage of .351.
• He is 10th in batting average, 35th in on-base percentage, and 20th in slugging among all qualifying hitters in baseball.
• Maikel Garcia has 154 hits this season and a team-best OBP of .354. He's batting .290 and slugging .465.
• Among qualifying hitters, he is 13th in batting average, 32nd in on-base percentage and 43rd in slugging percentage.
• Vinnie Pasquantino has 143 hits this season and has a slash line of .260/.321/.465.
• Salvador Perez is batting .235 with a .278 OBP and 81 RBI for Kansas City this season.

Guardians Player Leaders

• Jose Ramirez has accumulated 151 hits with a .360 on-base percentage, leading the Guardians in both categories. He's batting .287 and slugging .510.
• Including all the qualified players in MLB, his batting average places him 17th, his on-base percentage ranks 21st, and he is 16th in slugging.
• Ramirez heads into this game on a six-game hitting streak. In his last 10 games he is hitting .308 with three doubles, a triple, two home runs, two walks and eight RBIs.
• Steven Kwan's .379 slugging percentage leads his team. He has a batting average of .275 with an on-base percentage of .335.
• Including all qualifying players, he is 32nd in batting average, 60th in on-base percentage and 127th in slugging percentage.
• Kyle Manzardo is batting .239 with 15 doubles, two triples, 25 home runs and 45 walks.
• Angel Martinez is hitting .227 with 21 doubles, a triple, 10 home runs and 17 walks.

Royals vs Guardians Head to Head

• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/26/2025: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/12/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/11/2025: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 6-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 3/29/2025: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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