Florida vs South Florida Prediction, Odds, Picks, Best Bets for Week 2 2025

The Florida Gators versus the South Florida Bulls is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

Florida vs South Florida Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Florida: (-952) | South Florida: (+610)
• Spread: Florida: -17.5 (-118) | South Florida: +17.5 (-104)
• Total: 57.5 -- Over: (-110) | Under: (-110)

Florida vs South Florida Betting Trends

• Florida is unbeaten against the spread this season.
• Florida is unbeaten ATS (1-0) as a 17.5-point favorite or greater this year.
• South Florida has but one win versus the spread this year.
• South Florida and its opponent have yet to go over the total this season.

Florida vs South Florida Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gators win (93.6%)

Florida vs South Florida Point Spread

South Florida is a 17.5-point underdog against Florida. South Florida is -104 to cover the spread, and Florida is -118.

Florida vs South Florida Over/Under

Florida versus South Florida, on Sept. 6, has an over/under of 57.5, with the over being -110 and the under -110.

Florida vs South Florida Moneyline

The Florida vs South Florida moneyline has Florida as a -952 favorite, while South Florida is a +610 underdog.

Florida vs. South Florida Points Insights

• The Gators had an average implied point total of 31.9 last season, which is 6.1 points lower than their implied total in Saturday's game (38).
• The 34.3-point average implied total last season for the Bulls is 14.3 more points than the team's 20-point implied total in this matchup.

Florida vs. South Florida Game Info

• Game day: Saturday, September 6, 2025
• Game time: 4:15 p.m. ET
• TV channel: SEC Network
• Location: Gainesville, Florida
• Stadium: Ben Hill Griffin Stadium

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Check out even more in-depth Florida vs. South Florida analysis on FanDuel Research.