Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 2:12 p.m.

The MLB's Saturday schedule includes the Chicago Cubs taking on the Washington Nationals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Nationals Game Info

• Chicago Cubs (81-60) vs. Washington Nationals (56-84)
• Date: Saturday, September 6, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and MASN2

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-260) | WSH: (+215)
• Spread: CHC: -1.5 (-120) | WSH: +1.5 (-100)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 12-7, 2.94 ERA vs Brad Lord (Nationals) - 4-8, 4.34 ERA

This contest's pitching matchup is set, as the Cubs will send Matthew Boyd (12-7) to the mound, while Brad Lord (4-8) will answer the bell for the Nationals. Boyd and his team are 10-16-0 ATS this season when he starts. Boyd's team has been victorious in 55% of the games he's started as the moneyline favorite with a record of 11-9. The Nationals are 7-6-0 ATS in Lord's 13 starts that had a set spread. The Nationals are 7-4 in Lord's 11 starts this season that they were the underdog on the moneyline.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (69.4%)

Cubs vs Nationals Moneyline

• The Cubs vs Nationals moneyline has Chicago as a -260 favorite, while Washington is a +215 underdog on the road.

Cubs vs Nationals Spread

• The Cubs are 1.5-run home favorites on the runline against the Nationals. The Cubs are -120 to cover, and the Nationals are -100.

Cubs vs Nationals Over/Under

• A total of 8.5 runs has been set for the Cubs-Nationals contest on Sept. 6, with the over available at -118 and the under at -104.

Bet on Chicago Cubs vs. Washington Nationals on FanDuel today!

Cubs vs Nationals Betting Trends

• The Cubs have been victorious in 62, or 64.6%, of the 96 contests they have been chosen as favorites in this season.
• Chicago has been a -260 moneyline favorite on six occasions this season and won every time.
• Contests with the Cubs have gone over the total set by sportsbooks in 64 of 137 chances this season.
• The Cubs have posted a record of 63-74-0 against the spread this season.
• The Nationals have put together a 48-65 record in games they were the underdog on the moneyline (winning 42.5% of those games).
• In games it has played as a moneyline underdog with odds of +215 or longer, Washington has a 1-5 record (winning only 16.7% of its games).
• The Nationals have combined with opponents to hit the over on the total 71 times this season for a 71-56-7 record against the over/under.
• The Nationals are 66-68-0 against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .381 this season while batting .270 with 86 walks and 89 runs scored. He has a slugging percentage of .472.
• Among qualifying hitters in the majors, he ranks 42nd in batting average, eighth in on-base percentage, and 38th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (132) this season while batting .253 with 66 extra-base hits. He's slugging .494 with an on-base percentage of .291.
• He is 88th in batting average, 140th in on-base percentage and 26th in slugging among qualifying batters.
• Crow-Armstrong brings a two-game streak with at least one hit into this one. In his last five games he is batting .167 with two walks and three RBIs.
• Nico Hoerner has an OPS of .724, fueled by an OBP of .339 and a team-best slugging percentage of .386 this season.
• Seiya Suzuki has been key for Chicago with 126 hits, an OBP of .323 plus a slugging percentage of .468.

Nationals Player Leaders

• C.J. Abrams is batting .265 with 29 doubles, five triples, 17 home runs and 34 walks. He's slugging .446 with an on-base percentage of .327.
• He is 60th in batting average, 84th in on-base percentage and 67th in slugging percentage among all qualified batters in the big leagues.
• James Wood has 134 hits with a .353 OBP while slugging .470. Those stats all pace his team. He also has a batting average of .256.
• He ranks 86th in batting average, 36th in on-base percentage and 41st in slugging percentage in the big leagues.
• Luis Garcia has 26 doubles, a triple, 12 home runs and 23 walks while batting .260.
• Josh Bell is batting .225 with 13 doubles, a triple, 16 home runs and 54 walks.

Cubs vs Nationals Head to Head

• 9/5/2025: 11-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/4/2025: 2-0 WSH (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/3/2025: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2024: 5-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/20/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/19/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/1/2024: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/31/2024: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!