Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 2:12 p.m.

In MLB action on Friday, the Chicago Cubs face the Washington Nationals.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Nationals Game Info

• Chicago Cubs (80-60) vs. Washington Nationals (56-83)
• Date: Friday, September 5, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: Apple TV+

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-210) | WSH: (+176)
• Spread: CHC: -1.5 (-110) | WSH: +1.5 (-110)
• Total: 10.5 -- Over: (-110) | Under: (-110)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Javier Assad (Cubs) - 1-1, 4.05 ERA vs Jake Irvin (Nationals) - 8-10, 5.42 ERA

The Cubs will give the nod to Javier Assad (1-1, 4.05 ERA), who is eyeing win No. 2 on the season, and the Nationals will counter with Jake Irvin (8-10, 5.42 ERA). Assad and his team have not covered in any of the four games with a spread he's started this season. Assad has started three games with his team as the moneyline favorite and won each of them. The Nationals have gone 15-12-0 ATS in Irvin's 27 starts with a set spread. The Nationals have been the underdog on the moneyline in 26 of Irvin's starts this season, and they went 13-13 in those games.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (70.3%)

Cubs vs Nationals Moneyline

• Chicago is a -210 favorite on the moneyline, while Washington is a +176 underdog on the road.

Cubs vs Nationals Spread

• The Cubs are favored by 1.5 runs at home against the Nationals. The Cubs are -110 to cover the spread, while the Nationals are -110.

Cubs vs Nationals Over/Under

• An over/under of 10.5 has been set for Cubs-Nationals on Sept. 5, with the over being -110 and the under -110.

Bet on Chicago Cubs vs. Washington Nationals on FanDuel today!

Cubs vs Nationals Betting Trends

• The Cubs have been victorious in 61, or 64.2%, of the 95 contests they have been chosen as favorites in this season.
• This year Chicago has won 12 of 15 games when listed as at least -210 on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in 63 of 136 chances this season.
• The Cubs have an against the spread record of 62-74-0 in 136 games with a line this season.
• The Nationals have put together a 48-64 record in games they were the underdog on the moneyline (winning 42.9% of those games).
• In games it has played as a moneyline underdog with odds of +176 or longer, Washington has a 5-13 record (winning just 27.8% of its games).
• The Nationals have played in 133 games with an over/under set, and have combined with opponents to go over the total 70 times (70-56-7).
• The Nationals have gone 66-67-0 ATS this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.381) this season, fueled by 132 hits. He has a .270 batting average and a slugging percentage of .472.
• Among qualifying hitters, he is 45th in batting average, his on-base percentage ranks eighth, and he is 40th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (130) this season while batting .250 with 66 extra-base hits. He's slugging .493 with an on-base percentage of .290.
• Among qualified hitters, his batting average ranks him 95th, his on-base percentage 142nd, and his slugging percentage 25th.
• Nico Hoerner has hit five homers with a team-high .377 SLG this season.
• Seiya Suzuki has been key for Chicago with 125 hits, an OBP of .322 plus a slugging percentage of .470.

Nationals Player Leaders

• C.J. Abrams has 29 doubles, five triples, 17 home runs and 34 walks while batting .265. He's slugging .447 with an on-base percentage of .328.
• Including all the qualified players in the majors, his batting average is 59th, his on-base percentage ranks 82nd, and he is 70th in slugging.
• James Wood's 134 hits, .355 on-base percentage and .474 slugging percentage are all team-highs. He has a batting average of .258.
• Including all qualifying hitters, his batting average places him 84th, his on-base percentage is 33rd, and he is 39th in slugging.
• Luis Garcia is batting .260 with 26 doubles, a triple, 11 home runs and 23 walks.
• Josh Bell has 12 doubles, a triple, 16 home runs and 53 walks while hitting .224.

Cubs vs Nationals Head to Head

• 6/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/4/2025: 2-0 WSH (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/3/2025: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2024: 5-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/20/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/19/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/1/2024: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/31/2024: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/19/2023: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)

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