Blue Jays vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 6:12 a.m.

The Toronto Blue Jays are among the MLB teams playing on Wednesday, versus the Houston Astros.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Astros Game Info

• Toronto Blue Jays (83-61) vs. Houston Astros (78-67)
• Date: Wednesday, September 10, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and SCHN

Blue Jays vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-132) | HOU: (+112)
• Spread: TOR: -1.5 (+155) | HOU: +1.5 (-192)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Blue Jays vs Astros Probable Starting Pitchers

Probable Pitchers: José Berrios (Blue Jays) - 9-5, 4.02 ERA vs Jason Alexander (Astros) - 4-1, 4.68 ERA

This contest's pitching matchup is set, as the Blue Jays will send Jose Berrios (9-5) to the mound, while Jason Alexander (4-1) will take the ball for the Astros. Berrios' team is 17-11-0 against the spread this season in his starts. When Berrios starts a game and his team is the favorite on the moneyline, they have a record of 9-6. When Alexander starts, the Astros are 6-3-0 against the spread. The Astros were the moneyline underdog for four Alexander starts this season -- they won each time.

Blue Jays vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (60%)

Blue Jays vs Astros Moneyline

• Toronto is the favorite, -132 on the moneyline, while Houston is a +112 underdog on the road.

Blue Jays vs Astros Spread

• The Blue Jays are favored by 1.5 runs at home versus the Astros. The Blue Jays are +155 to cover the spread, while the Astros are -192.

Blue Jays vs Astros Over/Under

• The Blue Jays-Astros game on Sept. 10 has been given an over/under of 8.5 runs. The over is set at -122 and the under at -100.

Bet on Toronto Blue Jays vs. Houston Astros on FanDuel today!

Blue Jays vs Astros Betting Trends

• The Blue Jays have come away with 39 wins in the 67 contests they have been listed as the favorites in this season.
• Toronto has a record of 32-15 in contests when oddsmakers favor them by -132 or more on the moneyline.
• The Blue Jays and their opponents have gone over the total this season in 79 of their 143 opportunities.
• The Blue Jays are 84-59-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Astros have been the moneyline underdog 50 total times this season. They've finished 28-22 in those games.
• Houston has a 15-10 record (winning 60% of its games) when playing as a moneyline underdog of +112 or longer.
• The Astros have combined with opponents to hit the over on the total 65 times this season for a 65-75-4 record against the over/under.
• The Astros have gone 71-73-0 against the spread this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto in OBP (.396) this season, fueled by 158 hits. He has a .304 batting average and a slugging percentage of .500.
• Among all qualified batters in the majors, he ranks fifth in batting average, third in on-base percentage, and 21st in slugging.
• Guerrero hopes to build on an eight-game hitting streak in this matchup. In his last 10 games he is batting .439 with three doubles, two home runs, four walks and seven RBIs.
• George Springer has 128 hits, which is tops among Toronto batters this season. He's batting .300 with 50 extra-base hits. He's also slugging .550 with an on-base percentage of .393.
• Among qualified hitters, his batting average places him seventh, his on-base percentage fourth, and his slugging percentage sixth.
• Springer brings a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .200 with a double, two home runs, three walks and two RBIs.
• Ernie Clement has 133 hits this season and has a slash line of .275/.312/.398.
• Clement brings a four-game hitting streak into this game. In his last five games he is hitting .278 with three doubles, two walks and an RBI.
• Alejandro Kirk has 12 home runs, 65 RBI and a batting average of .291 this season.

Astros Player Leaders

• Jose Altuve has put up a team-best .440 slugging percentage. He's batting .263 with an on-base percentage of .327.
• Including all the qualified hitters in the big leagues, his batting average puts him 60th, his on-base percentage ranks 81st, and he is 71st in slugging.
• Jeremy Pena's 138 hits and .361 OBP both lead his team. He has a batting average of .303 while slugging .469.
• He is currently sixth in batting average, 20th in on-base percentage and 41st in slugging percentage among all qualifying batters.
• Yainer Diaz is hitting .254 with 21 doubles, a triple, 18 home runs and 20 walks.
• Carlos Correa is batting .274 with 24 doubles, 12 home runs and 38 walks.

Blue Jays vs Astros Head to Head

• 9/9/2025: 4-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/23/2025: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/22/2025: 5-1 HOU (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/21/2025: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/3/2024: 9-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/2/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/1/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/2/2024: 2-1 TOR (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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