Tennessee vs Louisville College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

The Tennessee Volunteers (7-3) aim to stop a three-game losing streak when they host the Louisville Cardinals (9-1) on December 16, 2025 at Thompson-Boling Arena. The contest airs on ESPN.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Tennessee vs. Louisville Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Knoxville, Tennessee
• Arena: Thompson-Boling Arena

Tennessee vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Tennessee win (64.6%)

Check out these betting insights and trends before you wager on Tuesday's Tennessee-Louisville spread (Tennessee -2.5) or total (157.5 points).

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Tennessee vs. Louisville: ATS Betting Stats and Trends

• Tennessee has covered three times in 10 matchups with a spread this season.
• Louisville is 7-3-0 ATS this season.
• Against the spread last season, the Volunteers played better at home, covering nine times in 17 home games, and five times in 11 road games.
• Against the spread last season, the Cardinals had better results on the road (9-2-0) than at home (8-9-0).

Tennessee vs. Louisville: Moneyline Betting Stats

• Tennessee has come away with four wins in the seven contests it has been listed as the moneyline favorite in this season.
• This year, the Volunteers have won four of six games when listed as at least -146 or better on the moneyline.
• This is the first time this season Louisville is listed as the moneyline underdog.
• The Cardinals have yet to play as a moneyline underdog of +122 or longer.
• Bookmakers have implied with the moneyline set for this matchup that Tennessee has a 59.3% chance of pulling out a win.

Tennessee vs. Louisville Head-to-Head Comparison

• Tennessee's +149 scoring differential (outscoring opponents by 14.9 points per game) is a result of scoring 80.9 points per game (112th in college basketball) while giving up 66.0 per contest (35th in college basketball).
• Ja'Kobi Gillespie paces Tennessee, scoring 17.3 points per game (117th in the nation).
• Louisville has a +262 scoring differential, topping opponents by 26.2 points per game. It is putting up 94.3 points per game, seventh in college basketball, and is giving up 68.1 per contest to rank 76th in college basketball.
• Ryan Conwell leads Louisville, recording 19.4 points per game (44th in college basketball).
• The 40.6 rebounds per game the Volunteers average rank sixth in the nation, and are 14.1 more than the 26.5 their opponents collect per outing.
• Nate Ament averages 7.1 rebounds per game (ranking 149th in college basketball) to lead the Volunteers.
• The Cardinals win the rebound battle by 9.5 boards on average. They record 40.5 rebounds per game, ninth in college basketball, while their opponents grab 31.0.
• Sananda Fru is 278th in college basketball with 6.2 rebounds per game, leading the Cardinals.
• Tennessee's 100.2 points per 100 possessions on offense rank 131st in college basketball, and the 81.7 points it allows per 100 possessions rank 26th in college basketball.
• The Cardinals average 112.3 points per 100 possessions on offense (eighth in college basketball), and give up 81.1 points per 100 possessions (20th in college basketball).

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