Sabres vs Blues NHL Prediction, Odds, Picks, Best Bets for Nov. 6

The NHL schedule on Thursday includes the Buffalo Sabres taking on the St. Louis Blues.

Get the latest NHL odds ahead of this matchup on FanDuel Sportsbook.

Sabres vs Blues Game Info

• Buffalo Sabres (5-4-4) vs. St. Louis Blues (4-8-2)
• Date: Thursday, November 6, 2025
• Time: 7 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Sabres vs Blues Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Blues Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (50.5%)

Sabres vs Blues Puck Line

• The Sabres are favored by 1.5 goals against the Blues. The Sabres are +172 to cover the spread, while the Blues are -215.

Sabres vs Blues Over/Under

• The over/under for the Sabres versus Blues game on Nov. 6 has been set at 6.5, with +104 odds on the over and -128 odds on the under.

Sabres vs Blues Moneyline

• The moneyline numbers for Sabres vs. Blues reveal Buffalo as the favorite (-137) and St. Louis as the underdog (+114) on the road.

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