Sabres vs Blues NHL Prediction, Odds, Picks, Best Bets for Nov. 6

The NHL's Thursday slate includes the Buffalo Sabres taking on the St. Louis Blues.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Sabres vs Blues Game Info

• Buffalo Sabres (5-4-4) vs. St. Louis Blues (4-8-2)
• Date: Thursday, November 6, 2025
• Time: 7 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Sabres vs Blues Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Blues Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (50%)

Sabres vs Blues Puck Line

• The Blues are 1.5-goal underdogs against the Sabres. The Blues are -215 to cover the spread, and the Sabres are +172.

Sabres vs Blues Over/Under

• The over/under for the Sabres versus Blues game on Nov. 6 has been set at 6.5, with +102 odds on the over and -124 odds on the under.

Sabres vs Blues Moneyline

• St. Louis is a +116 underdog on the moneyline, while Buffalo is a -140 favorite at home.

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