Iowa State vs Grambling College Basketball Prediction, Odds, Picks, Best Bets for Nov. 6

The Iowa State Cyclones (1-0) play the Grambling Tigers (1-0) on November 6, 2025. The matchup airs on ESPN+.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Grambling Game Info and Odds

• Game day: Thursday, November 6, 2025
• Game time: 8 p.m. ET
• TV channel: ESPN+
• Location: Ames, Iowa
• Arena: James H. Hilton Coliseum

Iowa State vs. Grambling Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (98.5%)

Before making a bet on Thursday's Iowa State-Grambling spread (Iowa State -33.5) or over/under (142.5 points), see the betting trends and insights below.

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Iowa State vs. Grambling: ATS Betting Stats and Trends

• Iowa State compiled a 20-15-0 ATS record last year.
• Grambling covered 14 times in 31 matchups with a spread last season.
• At home last season, the Cyclones sported a worse record against the spread (9-8-0) compared to their ATS record in road games (7-4-0).
• Last year, the Tigers were 2-8-0 at home against the spread (.200 winning percentage). On the road, they were 8-8-0 ATS (.500).

Iowa State vs. Grambling Head-to-Head Comparison

• On offense, Iowa State was the 34th-ranked squad in the nation (80.3 points per game) last year. On defense, it was 61st (68.3 points conceded per game).
• Iowa State grabbed 32.7 rebounds per game and conceded 28.3 boards last year, ranking 142nd and 31st, respectively, in college basketball.
• With 15 assists per game last season, Iowa State was 77th in the country.
• Iowa State was 232nd in college basketball in turnovers per game (11.6) and 13th-best in turnovers forced (14.4) last season.
• Grambling struggled to generate points last season, ranking 25th-worst in college basketball with 66.8 points per game. It played better defensively, ranking 52nd by allowing 67.7 points per contest.
• With 31 boards per game, Grambling ranked 234th in the nation. It ceded 32.4 rebounds per contest, which ranked 265th in college basketball.
• Grambling ranked 323rd in the nation with 11.4 assists per contest.
• Grambling averaged 12.2 turnovers per game (277th-ranked in college basketball). It forced 11.6 turnovers per contest (146th-ranked).

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