Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 1:12 p.m.

The MLB's Monday schedule includes the Boston Red Sox facing the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Red Sox vs Guardians Game Info

• Boston Red Sox (76-62) vs. Cleveland Guardians (68-67)
• Date: Monday, September 1, 2025
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CLEG

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-144) | CLE: (+122)
• Spread: BOS: -1.5 (+136) | CLE: +1.5 (-164)
• Total: 8 -- Over: (-112) | Under: (-108)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Brayan Bello (Red Sox) - 10-6, 2.99 ERA vs Parker Messick (Guardians) - 1-0, 0.66 ERA

The Red Sox will look to Brayan Bello (10-6) against the Guardians and Parker Messick (1-0). When Bello starts, his team is 14-9-0 against the spread this season. Bello's team has been victorious in 76.9% of the games he's started as the moneyline favorite with a record of 10-3. Messick has started two games with set spreads, and the Guardians went 1-1-0. The Guardians were named the moneyline underdog for one Messick start this season -- they lost.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (67.1%)

Red Sox vs Guardians Moneyline

• The moneyline numbers for Red Sox vs. Guardians reveal Boston as the favorite (-144) and Cleveland as the underdog (+122) on the road.

Red Sox vs Guardians Spread

• The Red Sox are hosting the Guardians and are favored by 1.5 runs (+136 to cover) on the runline. Cleveland is -164 to cover.

Red Sox vs Guardians Over/Under

• The over/under for Red Sox-Guardians on Sept. 1 is 8. The over is -112, and the under is -108.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have been favorites in 85 games this season and have come away with the win 50 times (58.8%) in those contests.
• Boston has a record of 18-14 when favored by -144 or more this year.
• Contests with the Red Sox have gone over the total set by bookmakers in 65 of 137 chances this season.
• The Red Sox are 74-63-0 against the spread in their 137 games with a line set by sportsbooks this season.
• The Guardians have won 32 of the 75 games they were listed as the moneyline underdog this season (42.7%).
• Cleveland has a record of 15-14 when it has played as a moneyline underdog with odds of +122 or longer (51.7%).
• The Guardians have had an over/under set by bookmakers 132 times, and have combined with opponents to go over the total in 59 of those games (59-68-5).
• The Guardians have a 69-63-0 record ATS this season.

Red Sox Player Leaders

• Jarren Duran has 138 hits and an OBP of .337 to go with a slugging percentage of .451. All three of those stats rank first among Boston hitters this season. He has a .260 batting average, as well.
• Among the qualified hitters in baseball, his batting average ranks 73rd, his on-base percentage ranks 62nd, and he is 62nd in slugging.
• Duran hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .333 with a double, a home run, two walks and three RBIs.
• Trevor Story is hitting .256 with 23 doubles, 22 home runs and 29 walks, while slugging .428 with an on-base percentage of .303.
• Among qualifying batters, he is 85th in batting average, 124th in on-base percentage and 80th in slugging percentage.
• Ceddanne Rafaela has collected 116 base hits, an OBP of .293 and a slugging percentage of .422 this season.
• Alex Bregman has 16 home runs, 53 RBI and a batting average of .287 this season.

Guardians Player Leaders

• Jose Ramirez has an on-base percentage of .357, a slugging percentage of .500, and has 139 hits, all club-highs for the Guardians (while batting .283).
• Including all qualifying hitters, he is 24th in batting average, while his on-base percentage is 28th and he is 20th in slugging.
• Steven Kwan is slugging .377 to pace his team. He has a batting average of .270 with an on-base percentage of .329.
• Including all qualified players, he is 44th in batting average, 81st in on-base percentage and 133rd in slugging percentage.
• Kyle Manzardo is hitting .233 with 14 doubles, two triples, 23 home runs and 41 walks.
• Angel Martinez is hitting .225 with 21 doubles, a triple, 10 home runs and 16 walks.

Red Sox vs Guardians Head to Head

• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/25/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/24/2024: 8-0 BOS (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/23/2024: 4-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 2-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2024: 10-7 CLE (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/15/2024: 6-0 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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