Syracuse vs UConn Prediction, Odds, Picks, Best Bets for Week 2 2025

On Saturday in college football, the Syracuse Orange are up against the UConn Huskies.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Syracuse vs UConn Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Syracuse: (-250) | UConn: (+202)
• Spread: Syracuse: -6.5 (-122) | UConn: +6.5 (100)
• Total: 58.5 -- Over: (-105) | Under: (-115)

Syracuse vs UConn Betting Trends

• Syracuse is winless against the spread this season.
• Syracuse and its opponent have not failed to hit the over in any game this season.
• UConn is unbeaten against the spread this season.
• UConn has had one game (of one) go over the total this season.

Syracuse vs UConn Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Orange win (69.6%)

Syracuse vs UConn Point Spread

Syracuse is favored by 6.5 points versus UConn. Syracuse is -122 to cover the spread, while UConn is +100.

Syracuse vs UConn Over/Under

Syracuse versus UConn on Sept. 6 has an over/under of 58.5 points, with the over -105 and the under -115.

Syracuse vs UConn Moneyline

Looking at the moneyline for Syracuse-UConn, Syracuse is the favorite at -250, and UConn is +202.

Syracuse vs. UConn Points Insights

• The average implied total for the Orange last season was 33.4 points, 0.4 more points than their implied total of 33 points in Saturday's game.
• The 29.3-point average implied total last season for the Huskies is 3.3 more points than the team's 26-point implied total in this matchup.

Syracuse vs. UConn Game Info

• Game day: Saturday, September 6, 2025
• Game time: 12 p.m. ET
• TV channel: ACC Network Extra
• Location: Syracuse, New York
• Stadium: JMA Wireless Dome

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Check out even more in-depth Syracuse vs. UConn analysis on FanDuel Research.