Iowa State vs Iowa Prediction, Odds, Picks, Best Bets for Week 2 2025

The Iowa State Cyclones versus the Iowa Hawkeyes is on the college football schedule for Saturday.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Iowa State vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-156) | Iowa: (+130)
• Spread: Iowa State: -3.5 (-102) | Iowa: +3.5 (-120)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Iowa State vs Iowa Betting Trends

• Iowa State hasn't lost a game against the spread this year.
• Iowa State is unbeaten ATS (1-0) as a 3.5-point favorite or greater this season.
• One of two Iowa State games have gone over the point total this year.
• Iowa is winless against the spread this year.
• Iowa and its opponent have yet to go over the total this year.

Iowa State vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hawkeyes win (51.4%)

Iowa State vs Iowa Point Spread

Iowa is the underdog by 3.5 points against Iowa State. Iowa is -102 to cover the spread, and Iowa State is -120.

Iowa State vs Iowa Over/Under

The over/under for Iowa State-Iowa on Sept. 6 is 41.5. The over is -110, and the under is -110.

Iowa State vs Iowa Moneyline

Looking at the moneyline for Iowa-Iowa State, Iowa is the underdog at +130, and Iowa State is -156.

Iowa State vs. Iowa Points Insights

• The average implied total for the Cyclones last season was 29.0 points, 6.0 more points than their implied total of 23 points in Saturday's game.
• The 23.9-point average implied total last season for the Hawkeyes is 4.9 more points than the team's 19-point implied total in this matchup.

Iowa State vs. Iowa Game Info

• Game day: Saturday, September 6, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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Check out even more in-depth Iowa State vs. Iowa analysis on FanDuel Research.