Pirates vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 2:12 a.m.

The Friday slate in MLB includes a matchup between the Pittsburgh Pirates and the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Pirates vs Athletics Game Info

• Pittsburgh Pirates (65-88) vs. Athletics (72-81)
• Date: Friday, September 19, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and NBCS-CA

Pirates vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-112) | OAK: (-104)
• Spread: PIT: +1.5 (-194) | OAK: -1.5 (+162)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Pirates vs Athletics Probable Starting Pitchers

Probable Pitchers: Mitch Keller (Pirates) - 6-14, 4.13 ERA vs Luis Severino (Athletics) - 6-11, 4.82 ERA

The Pirates will call on Mitch Keller (6-14) versus the Athletics and Luis Severino (6-11). Keller's team is 16-13-0 against the spread in his starts this season. Keller's team has a record of 2-4 this season when he starts and they are the favorite on the moneyline. The Athletics are 12-14-0 against the spread when Severino starts. The Athletics have a 9-13 record in Severino's 22 starts this season when they were the moneyline underdog.

Pirates vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.3%)

Pirates vs Athletics Moneyline

• The Pirates vs Athletics moneyline has the Pirates as a -112 favorite, while the Athletics are a -104 underdog on the road.

Pirates vs Athletics Spread

• The Pirates are hosting the Athletics and are 1.5 on the runline and -194 to cover, while Sacramento is +162 to cover the spread.

Pirates vs Athletics Over/Under

• A combined run total of 8.5 has been set for Pirates-Athletics on Sept. 19, with the over at -115 and the under at -105.

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Pirates vs Athletics Betting Trends

• The Pirates have been chosen as favorites in 40 games this year and have walked away with the win 20 times (50%) in those games.
• This year, the Pirates have won 20 of 38 games when listed as at least -112 or better on the moneyline.
• The Pirates and their opponents have hit the over in 56 of their 145 games with a total this season.
• The Pirates are 77-68-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Athletics have gone 53-61 in games they were the underdog on the moneyline (winning 46.5% of those games).
• The Athletics have gone 50-59 when playing as a moneyline underdog with odds of -104 or longer (45.9%).
• The Athletics have combined with their opponents to go over the total 74 times this season for a 74-71-7 record against the over/under.
• The Athletics have an 82-70-0 record ATS this season.

Pirates Player Leaders

• Bryan Reynolds has 134 hits to go with a slugging percentage of .396, both of which lead Pittsburgh hitters this season. He has a .241 batting average and an on-base percentage of .311.
• Among all qualified batters, he is 107th in batting average, his on-base percentage ranks 107th, and he is 107th in slugging.
• Andrew McCutchen has 108 hits this season and a team-best OBP of .335. He's batting .239 and slugging .375.
• His batting average is 114th among qualified players, his on-base percentage 59th, and his slugging percentage 127th.
• Oneil Cruz has 91 hits this season and has a slash line of .203/.304/.384.
• Spencer Horwitz is batting .260 with a .338 OBP and 42 RBI for Pittsburgh this season.
• Horwitz heads into this matchup on a three-game hitting streak. During his last five outings he is batting .357 with a double, a home run, four walks and two RBIs.

Athletics Player Leaders

• Brent Rooker has a .494 slugging percentage, which paces the Athletics. He's batting .267 with an on-base percentage of .339.
• Including all qualified hitters in the big leagues, his batting average places him 44th, his on-base percentage is 51st, and he is 22nd in slugging.
• Tyler Soderstrom is batting .278 with 31 doubles, a triple, 24 home runs and 53 walks. He's slugging .475 with an on-base percentage of .348.
• Including all qualifying hitters, his batting average puts him 29th, his on-base percentage ranks 39th, and he is 33rd in slugging.
• Nick Kurtz is batting .294 with 25 doubles, two triples, 32 home runs and 60 walks.
• Jacob Wilson's .363 OBP paces his team.

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