NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 5

The NFL schedule in Week 5, which includes the Tampa Bay Buccaneers squaring off against the Seattle Seahawks, is not one to miss.

With Week 5 in the NFL upon us, stay on top of the latest betting odds with our preview below.

Rams vs. 49ers

The Los Angeles Rams (3-1), who grabbed a win against the Colts in their previous game, host the San Francisco 49ers (3-1) at SoFi Stadium on Oct. 2 at 8:15 p.m. ET. The 49ers lost to the Jaguars in their last game.

• Game Preview: San Francisco 49ers at Los Angeles Rams
• Projected Favorite: Rams (60.78% win probability)
• Spread: Los Angeles (-7.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Los Angeles vs. San Francisco with FanDuel Sportsbook.

Browns vs. Vikings

At 9:30 a.m. ET on Sunday, the Minnesota Vikings (2-2) take on the Cleveland Browns (1-3).

• Game Preview: Minnesota Vikings vs. Cleveland Browns
• Projected Favorite: Vikings (73.34% win probability)
• Spread: Minnesota (-3.5)
• Total: 35.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Cleveland vs. Minnesota with FanDuel Sportsbook.

Ravens vs. Texans

At 1 p.m. ET on Sunday, the Baltimore Ravens (1-3) are at home against the Houston Texans (1-3).

• Game Preview: Houston Texans at Baltimore Ravens
• Projected Favorite: Ravens (65.51% win probability)
• Spread: Houston (-1.5)
• Total: 40.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Houston with FanDuel Sportsbook.

Jets vs. Cowboys

The Dallas Cowboys (1-2-1), owners of the fifth-ranked scoring offense in the NFL (28.5 points per game), will look to take advantage of the New York Jets' (0-4) 28th-ranked scoring defense (30.0 points conceded per game) when the Cowboys visit the Jets on Sunday, Oct. 5 at MetLife Stadium. The game starts at 1 p.m. ET.

• Game Preview: Dallas Cowboys at New York Jets
• Projected Favorite: Cowboys (51.65% win probability)
• Spread: Dallas (-2.5)
• Total: 47.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Dallas with FanDuel Sportsbook.

Panthers vs. Dolphins

At 1 p.m. ET on Sunday, the Carolina Panthers (1-3) are at home against the Miami Dolphins (1-3).

• Game Preview: Miami Dolphins at Carolina Panthers
• Projected Favorite: Dolphins (55.41% win probability)
• Spread: Miami (-1.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Miami with FanDuel Sportsbook.

Eagles vs. Broncos

The Philadelphia Eagles (4-0), who took home the victory against the Buccaneers in their last tilt, host the Denver Broncos (2-2) at Lincoln Financial Field on Oct. 5 at 1 p.m. ET. The Broncos grabbed a win against the Bengals in their last game.

• Game Preview: Denver Broncos at Philadelphia Eagles
• Projected Favorite: Eagles (68.77% win probability)
• Spread: Philadelphia (-4.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Denver with FanDuel Sportsbook.

Colts vs. Raiders

The Indianapolis Colts (3-1), who were taken down by the Rams in their last game, host the Las Vegas Raiders (1-3) at Lucas Oil Stadium on Oct. 5 at 1 p.m. ET. The Raiders took the L against the Bears in their last game.

• Game Preview: Las Vegas Raiders at Indianapolis Colts
• Projected Favorite: Colts (73.31% win probability)
• Spread: Indianapolis (-6.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Las Vegas with FanDuel Sportsbook.

Saints vs. Giants

The New Orleans Saints (0-4) are in action on Sunday at 1 p.m. ET versus the New York Giants (1-3) at Caesars Superdome.

• Game Preview: New York Giants at New Orleans Saints
• Projected Favorite: Saints (65.97% win probability)
• Spread: New Orleans (-1.5)
• Total: 41.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New Orleans vs. New York with FanDuel Sportsbook.

Seahawks vs. Buccaneers

One of the best pass-catchers in football will be featured when Emeka Egbuka and the Tampa Bay Buccaneers (3-1) visit the Seattle Seahawks (3-1) on Sunday, October 5, 2025.

• Game Preview: Tampa Bay Buccaneers at Seattle Seahawks
• Projected Favorite: Seahawks (51.05% win probability)
• Spread: Seattle (-3)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Seattle vs. Tampa Bay with FanDuel Sportsbook.

Cardinals vs. Titans

The Arizona Cardinals (2-2), who were defeated by the Seahawks in their last tilt, host the Tennessee Titans (0-4) at State Farm Stadium on Oct. 5 at 4:05 p.m. ET. The Titans took the L against the Texans in their last game.

• Game Preview: Tennessee Titans at Arizona Cardinals
• Projected Favorite: Cardinals (86.59% win probability)
• Spread: Arizona (-8.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Tennessee with FanDuel Sportsbook.

Chargers vs. Commanders

When the Los Angeles Chargers (3-1) and the Washington Commanders (2-2) meet on Sunday, Oct. 5 at 4:25 p.m. ET, they will both be aiming to right the ship after losing their previous contest. The Chargers lost 21-18 to the Giants, and the Commanders are coming off a 34-27 loss to the Falcons.

• Game Preview: Washington Commanders at Los Angeles Chargers
• Projected Favorite: Chargers (58.27% win probability)
• Spread: Los Angeles (-2.5)
• Total: 47.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Washington with FanDuel Sportsbook.

Bengals vs. Lions

Star running back Jahmyr Gibbs and the Detroit Lions (3-1) play the Cincinnati Bengals (2-2) on Sunday at 4:25 p.m. ET at Paycor Stadium.

• Game Preview: Detroit Lions at Cincinnati Bengals
• Projected Favorite: Lions (76.94% win probability)
• Spread: Detroit (-10.5)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Cincinnati vs. Detroit with FanDuel Sportsbook.

Bills vs. Patriots

James Cook and the Buffalo Bills (4-0) will host Drake Maye and the New England Patriots (2-2) on Sunday at 8:20 p.m. ET, in a matchup between two of the biggest offensive stars in football.

• Game Preview: New England Patriots at Buffalo Bills
• Projected Favorite: Bills (77.54% win probability)
• Spread: Buffalo (-8.5)
• Total: 49.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Buffalo vs. New England with FanDuel Sportsbook.

Jaguars vs. Chiefs

On Monday at 8:15 p.m. ET, two of the top offensive players in football will be featured when QB Patrick Mahomes and the Kansas City Chiefs (2-2) visit running back Travis Etienne and the Jacksonville Jaguars (3-1).

• Game Preview: Kansas City Chiefs at Jacksonville Jaguars
• Projected Favorite: Chiefs (62.86% win probability)
• Spread: Kansas City (-3)
• Total: 46.5 -- Over: (-102) | Under: (-120)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Jacksonville vs. Kansas City with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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