Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 5:19 a.m.

The MLB slate on Thursday includes the Cleveland Guardians taking on the Kansas City Royals.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Royals Game Info

• Cleveland Guardians (74-71) vs. Kansas City Royals (74-72)
• Date: Thursday, September 11, 2025
• Time: 7:15 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: FOX

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | KC: (+114)
• Spread: CLE: -1.5 (+146) | KC: +1.5 (-178)
• Total: 8 -- Over: (-106) | Under: (-114)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 10-5, 3.17 ERA vs Stephen Kolek (Royals) - 5-5, 3.88 ERA

The Guardians will call on Gavin Williams (10-5) against the Royals and Stephen Kolek (5-5). Williams' team is 13-15-0 against the spread this season in his starts. Williams' team is 6-4 this season when he starts and they are the moneyline favorite. The Royals have an 11-5-0 record against the spread in Kolek's starts. The Royals are 4-5 in Kolek's nine starts this season that they were the moneyline underdog.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.1%)

Guardians vs Royals Moneyline

• Kansas City is a +114 underdog on the moneyline, while Cleveland is a -134 favorite at home.

Guardians vs Royals Spread

• The Guardians are 1.5-run home favorites on the runline against the Royals. The Guardians are +146 to cover, and the Royals are -178.

Guardians vs Royals Over/Under

• The over/under for Guardians-Royals on Sept. 11 is 8. The over is -106, and the under is -114.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have been chosen as favorites in 58 games this year and have walked away with the win 36 times (62.1%) in those games.
• Cleveland has a record of 16-7 in contests when oddsmakers favor them by -134 or more on the moneyline.
• The Guardians and their opponents have hit the over in 63 of their 142 games with a total set by oddsmakers this season.
• The Guardians are 76-66-0 against the spread in their 142 games that had a posted line this season.
• The Royals have been the moneyline underdog 82 total times this season. They've gone 38-44 in those games.
• Kansas City has a 19-22 record (winning 46.3% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Royals have played in 144 games with an over/under set, and have combined with opponents to go over the total 60 times (60-82-2).
• The Royals have a 70-74-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.361) and total hits (152) this season. He's batting .287 batting average while slugging .511.
• He is 17th in batting average, 20th in on-base percentage, and 15th in slugging among all qualified hitters in the majors.
• Ramirez will look for his eighth straight game with a hit in this contest. During his last 10 outings he is hitting .342 with four doubles, a triple, two home runs, three walks and eight RBIs.
• Steven Kwan has an OPS of .714, fueled by an OBP of .335 and a team-best slugging percentage of .379 this season. He's batting .276.
• Among qualifying hitters, he ranks 31st in batting average, 60th in on-base percentage and 126th in slugging percentage.
• Kyle Manzardo has collected 98 base hits, an OBP of .325 and a slugging percentage of .477 this season.
• Manzardo has picked up a hit in three games in a row. During his last five outings he is batting .400 with a double, two home runs, four walks and five RBIs.
• Angel Martinez is batting .225 with a .264 OBP and 41 RBI for Cleveland this season.

Royals Player Leaders

• Bobby Witt Jr. has accumulated a slugging percentage of .501 and has 163 hits, both team-best numbers for the Royals. He's batting .295 and with an on-base percentage of .352.
• He is eighth in batting average, 34th in on-base percentage and 20th in slugging percentage among all qualifying hitters in the majors.
• Maikel Garcia has a .355 OBP to lead his team. He has a batting average of .292 while slugging .467.
• He is currently 11th in batting average, 30th in on-base percentage and 42nd in slugging percentage among all qualified hitters.
• Vinnie Pasquantino is batting .262 with 24 doubles, a triple, 29 home runs and 44 walks.
• Salvador Perez is hitting .235 with 34 doubles, 25 home runs and 23 walks.

Guardians vs Royals Head to Head

• 9/10/2025: 4-3 KC (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/26/2025: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/12/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/11/2025: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 6-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

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