Duke vs Lipscomb College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

Two hot teams hit the court when the Duke Blue Devils (10-0) host the Lipscomb Bisons (6-4) on December 16, 2025. The Blue Devils will put their 10-game win streak on the line against the Bisons, who have won five straight.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Lipscomb Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 6 p.m. ET
• TV channel: ACC Network
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Duke vs. Lipscomb Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (94.8%)

Before you bet on Tuesday's Duke-Lipscomb spread (Duke -31.5) or total (151.5 points), see the betting insights and trends below.

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Duke vs. Lipscomb: ATS Betting Stats and Trends

• Duke has put together a 6-4-0 record against the spread this season.
• Lipscomb has covered six times in nine matchups with a spread this year.
• When playing at home last season, the Blue Devils owned a worse record against the spread (11-6-0) compared to their ATS record on the road (9-2-0).
• Against the spread, the Bisons have an identical winning percentage (.667) at home (2-1-0 record) and away (4-2-0).

Duke vs. Lipscomb Head-to-Head Comparison

• Duke has a +272 scoring differential, topping opponents by 27.2 points per game. It is putting up 86.8 points per game to rank 45th in college basketball and is allowing 59.6 per outing to rank fourth in college basketball.
• Cameron Boozer's 23.0 points per game lead Duke and rank first in college basketball.
• Lipscomb has a +66 scoring differential, topping opponents by 6.6 points per game. It is putting up 80.4 points per game, 126th in college basketball, and is giving up 73.8 per contest to rank 200th in college basketball.
• Grant Asman's 13.3 points per game leads Lipscomb and ranks 474th in the nation.
• The Blue Devils rank 15th in the country at 39.3 rebounds per game. That's 9.3 more than the 30.0 their opponents average.
• Boozer tops the Blue Devils with 9.9 rebounds per game (18th in college basketball play).
• The Bisons average 33.7 rebounds per game (166th in college basketball), compared to the 34.1 of their opponents.
• Asman paces the Bisons with 6.4 rebounds per game (248th in college basketball).
• Duke averages 108.8 points per 100 possessions on offense (28th in college basketball), and allows 74.7 points per 100 possessions (first in college basketball).
• The Bisons rank 162nd in college basketball with 98.3 points scored per 100 possessions, and 147th defensively with 90.2 points conceded per 100 possessions.

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