Virginia vs Duke Prediction, Odds, Picks, Best Bets for ACC Championship Game 2025

The college football schedule on Saturday includes the Virginia Cavaliers taking on the Duke Blue Devils.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding today's NCAA football betting odds.

Virginia vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Virginia: (-166) | Duke: (+138)
• Spread: Virginia: -3.5 (-110) | Duke: +3.5 (-110)
• Total: 57.5 -- Over: (-115) | Under: (-105)

Virginia vs Duke Betting Trends

• Virginia has eight wins in 12 games against the spread this season.
• As 3.5-point favorites or more, Virginia is 5-3 against the spread.
• Virginia has played 12 games this year, and five of them have hit the over.
• Duke's record against the spread in 2025 is 6-6-0.
• Duke has yet to lose ATS (1-0) as a 3.5-point underdog or more this year.
• There have been nine Duke games (out of 12) that hit the over this year.

Virginia vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (66.2%)

Virginia vs Duke Point Spread

Duke is the underdog by 3.5 points against Virginia. Duke is -110 to cover the spread, and Virginia is -110.

Virginia vs Duke Over/Under

A combined point total of 57.5 has been set for Virginia-Duke on Dec. 6, with the over at -115 and the under at -105.

Virginia vs Duke Moneyline

Virginia is a -166 favorite on the moneyline, while Duke is a +138 underdog.

Virginia vs. Duke Points Insights

Virginia vs. Duke Game Info

• Game day: Saturday, December 6, 2025
• Game time: 8 p.m. ET
• TV channel: ABC
• Location: Charlotte, North Carolina
• Stadium: Bank of America Stadium

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Check out even more in-depth Virginia vs. Duke analysis on FanDuel Research.