SMU vs Louisville Prediction, Odds, Picks, Best Bets for Week 13 2025

The SMU Mustangs versus the Louisville Cardinals is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

SMU vs Louisville Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SMU: (-137) | Louisville: (+114)
• Spread: SMU: -2.5 (-115) | Louisville: +2.5 (-105)
• Total: 53.5 -- Over: (-105) | Under: (-115)

SMU vs Louisville Betting Trends

• SMU's record against the spread is 4-5-0.
• SMU has two wins ATS (2-4) as a 2.5-point or higher favorite in 2025.
• There have been three SMU games (of nine) that hit the over this season.
• Louisville has covered the spread three times in 10 games.
• Louisville has covered every time (1-0) as a 2.5-point or greater underdog this year.
• Of 10 Louisville games so far this year, five have gone over the total.

SMU vs Louisville Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50%)

SMU vs Louisville Point Spread

SMU is favored by 2.5 points over Louisville. SMU is -115 to cover the spread, with Louisville being -105.

SMU vs Louisville Over/Under

SMU versus Louisville on Nov. 22 has an over/under of 53.5 points, with the over -105 and the under -115.

SMU vs Louisville Moneyline

SMU is the favorite, -137 on the moneyline, while Louisville is a +114 underdog.

SMU vs. Louisville Points Insights

SMU vs. Louisville Game Info

• Game day: Saturday, November 22, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: University Park, Texas
• Stadium: Gerald J. Ford Stadium

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Check out even more in-depth SMU vs. Louisville analysis on FanDuel Research.