LSU vs Western Kentucky Prediction, Odds, Picks, Best Bets for Week 13 2025

The LSU Tigers versus the Western Kentucky Hilltoppers is on the college football schedule for Saturday.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

LSU vs Western Kentucky Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LSU: (-1786) | Western Kentucky: (+980)
• Spread: LSU: -21.5 (-110) | Western Kentucky: +21.5 (-110)
• Total: 48.5 -- Over: (-110) | Under: (-110)

LSU vs Western Kentucky Betting Trends

• LSU's record against the spread is 3-7-0.
• LSU has no wins ATS (0-2) as a 21.5-point favorite or greater this season.
• This season, three of LSU's 10 games have hit the over.
• Western Kentucky is 8-2-0 against the spread this year.
• There have been five Western Kentucky games (out of 10) that hit the over this season.

LSU vs Western Kentucky Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (93.8%)

LSU vs Western Kentucky Point Spread

LSU is a 21.5-point favorite against Western Kentucky. LSU is -110 to cover the spread, and Western Kentucky is -110.

LSU vs Western Kentucky Over/Under

The LSU-Western Kentucky game on Nov. 22 has been given an over/under of 48.5 points. The over is -110 and the under is -110.

LSU vs Western Kentucky Moneyline

The moneyline numbers for LSU vs. Western Kentucky reveal LSU as the favorite (-1786) and Western Kentucky as the underdog (+980).

LSU vs. Western Kentucky Points Insights

LSU vs. Western Kentucky Game Info

• Game day: Saturday, November 22, 2025
• Game time: 7:45 p.m. ET
• TV channel: SEC Network
• Location: Baton Rouge, Louisiana
• Stadium: Tiger Stadium

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Check out even more in-depth LSU vs. Western Kentucky analysis on FanDuel Research.