Phillies vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:11 a.m.

In MLB action on Monday, the Philadelphia Phillies play the Boston Red Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Phillies vs Red Sox Game Info

• Philadelphia Phillies (56-43) vs. Boston Red Sox (54-47)
• Date: Monday, July 21, 2025
• Time: 6:45 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and NESN

Phillies vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-210) | BOS: (+176)
• Spread: PHI: -1.5 (-110) | BOS: +1.5 (-110)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Phillies vs Red Sox Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 9-3, 2.36 ERA vs Walker Buehler (Red Sox) - 6-6, 6.12 ERA

The probable starters are Zack Wheeler (9-3) for the Phillies and Walker Buehler (6-6) for the Red Sox. When Wheeler starts, his team is 10-9-0 against the spread this season. Wheeler's team is 13-4 this season when he starts and they are the moneyline favorite. When Buehler starts, the Red Sox are 8-8-0 against the spread. The Red Sox have been the underdog on the moneyline in six of Buehler's starts this season, and they went 2-4 in those games.

Phillies vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.9%)

Phillies vs Red Sox Moneyline

• Looking at the moneyline for Phillies-Red Sox, Philadelphia is the favorite at -210, and Boston is +176 playing on the road.

Phillies vs Red Sox Spread

• The Phillies are hosting the Red Sox and are favored by 1.5 runs on the spread. The Phillies are -110 to cover the runline, with the Red Sox being -110.

Phillies vs Red Sox Over/Under

• Phillies versus Red Sox, on July 21, has an over/under of 8.5, with the over being -102 and the under -120.

Bet on Philadelphia Phillies vs. Boston Red Sox on FanDuel today!

Phillies vs Red Sox Betting Trends

• The Phillies have come away with 48 wins in the 74 contests they have been listed as the favorites in this season.
• This season Philadelphia has been victorious 12 times in 14 chances when named as a favorite of at least -210 on the moneyline.
• The Phillies and their opponents have gone over the total this season in 37 of their 93 opportunities.
• The Phillies have posted a record of 47-46-0 against the spread this season.
• The Red Sox have won 43.8% of the games this season they were the moneyline underdog (14-18).
• Boston has played as a moneyline underdog of +176 or longer in just two games this season, which it split 1-1.
• The Red Sox have played in 100 games with a set over/under, and have combined with their opponents to go over the total 47 times (47-49-4).
• The Red Sox have a 54-46-0 record against the spread this season.

Phillies Player Leaders

• Kyle Schwarber has 91 hits and an OBP of .380, both of which rank first among Philadelphia hitters this season. He has a .251 batting average and a slugging percentage of .559.
• Among qualifying hitters in MLB, his batting average ranks 94th, his on-base percentage ranks ninth, and he is seventh in slugging.
• Schwarber hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .200 with a double, two home runs, three walks and five RBIs.
• Trea Turner leads Philadelphia in slugging percentage (.429) thanks to 32 extra-base hits. He's batting .288 with an on-base percentage of .344.
• His batting average ranks 20th among qualified players, his on-base percentage 56th, and his slugging percentage 74th.
• Turner enters this game looking to extend his three-game hit streak. In his last five games he is hitting .211 with a double, three walks and an RBI.
• Bryce Harper is batting .268 with a .491 slugging percentage and 41 RBI this year.
• Nick Castellanos is batting .270 with a .313 OBP and 52 RBI for Philadelphia this season.

Red Sox Player Leaders

• Ceddanne Rafaela has racked up 88 hits, a team-best for the Red Sox. He's batting .267 and slugging .471 with an on-base percentage of .309.
• Including all the qualifying players in the majors, he ranks 63rd in batting average, 117th in on-base percentage and 40th in slugging percentage.
• Jarren Duran's .322 OBP and .427 slugging percentage both pace his team. He has a batting average of .257.
• Including all qualifying players, he is 84th in batting average, 92nd in on-base percentage and 76th in slugging percentage.
• Wilyer Abreu has 11 doubles, 20 home runs and 31 walks while batting .256.
• Trevor Story is batting .249 with 13 doubles, 15 home runs and 19 walks.

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