Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 3

Odds updated as of 3:11 p.m.

The Sunday slate in MLB includes a matchup between the San Diego Padres and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Padres vs Cardinals Game Info

• San Diego Padres (61-50) vs. St. Louis Cardinals (56-56)
• Date: Sunday, August 3, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSMW

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | STL: (+124)
• Spread: SD: -1.5 (+142) | STL: +1.5 (-172)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 3-10, 4.79 ERA vs Andre Pallante (Cardinals) - 6-7, 4.62 ERA

The Padres will give the nod to Dylan Cease (3-10, 4.79 ERA), who is eyeing win No. 4 on the season, and the Cardinals will counter with Andre Pallante (6-7, 4.62 ERA). Cease's team is 9-13-0 against the spread this season in his starts. Cease's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 9-6. When Pallante starts, the Cardinals have gone 12-9-0 against the spread. The Cardinals are 6-6 in Pallante's 12 starts this season that they were the moneyline underdog.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.6%)

Padres vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Padres, St. Louis is the underdog at +124, and San Diego is -146 playing at home.

Padres vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Padres. The Cardinals are -172 to cover, and the Padres are +142.

Padres vs Cardinals Over/Under

• Padres versus Cardinals on Aug. 3 has an over/under of 8.5 runs, with the odds on the over -118 and the under set at -104.

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Padres vs Cardinals Betting Trends

• The Padres have been victorious in 33, or 60%, of the 55 contests they have been chosen as favorites in this season.
• San Diego has a record of 19-11 when favored by -146 or more this year.
• The Padres and their opponents have hit the over in 45 of their 109 games with a total set by oddsmakers this season.
• The Padres are 60-49-0 against the spread in their 109 games that had a posted line this season.
• The Cardinals have been the underdog on the moneyline 56 total times this season. They've finished 28-28 in those games.
• When it has played as a moneyline underdog with odds of +124 or longer, St. Louis has a 7-12 record (winning only 36.8% of its games).
• The Cardinals have played in 109 games with a set over/under, and have combined with their opponents to go over the total 55 times (55-49-5).
• The Cardinals have a 57-52-0 record against the spread this season (covering 52.3% of the time).

Padres Player Leaders

• Manny Machado has 129 hits to go with a slugging percentage of .505, both of which are best among San Diego hitters this season. He has a .301 batting average and an on-base percentage of .360.
• Among qualified hitters in the majors, he is eighth in batting average, 31st in on-base percentage, and 19th in slugging.
• Machado has picked up at least one hit in 10 straight games. During his last 10 games he is batting .476 with four doubles, two home runs and 12 RBIs.
• Fernando Tatis Jr. has 18 doubles, two triples, 17 home runs and 61 walks. He's batting .264 and slugging .441 with an on-base percentage of .365.
• His batting average is 68th among qualified players, his on-base percentage 22nd, and his slugging percentage 70th.
• Luis Arraez is batting .299 with a .409 slugging percentage and 41 RBI this year.
• Arraez has logged a hit or more in 15 straight games. In his last 10 outings he is batting .425 with three doubles, a home run, three walks and four RBIs.
• Xander Bogaerts is batting .269 with a .340 OBP and 37 RBI for San Diego this season.
• Bogaerts has safely hit in three straight games. During his last five outings he is hitting .333 with a double, a walk and an RBI.

Cardinals Player Leaders

• Brendan Donovan has put up a team-high OBP (.353) and slugging percentage (.410). He's batting .281.
• Including all the qualifying hitters in MLB, he ranks 29th in batting average, 43rd in on-base percentage and 96th in slugging percentage.
• Alec Burleson's 97 hits lead his team. He has a batting average of .284 while slugging .463 with an on-base percentage of .341.
• His batting average is 26th among all qualified players, his on-base percentage ranks 57th, and he is 50th in slugging.
• Willson Contreras has 29 doubles, 15 home runs and 34 walks while hitting .257.
• Masyn Winn is batting .273 with 24 doubles, seven home runs and 27 walks.

Padres vs Cardinals Head to Head

• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)

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