Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 25

Odds updated as of 7:11 p.m.

MLB action on Friday includes the San Diego Padres taking on the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Padres vs Cardinals Game Info

• San Diego Padres (55-48) vs. St. Louis Cardinals (53-51)
• Date: Friday, July 25, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SDPA

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-130) | STL: (+110)
• Spread: SD: -1.5 (+130) | STL: +1.5 (-156)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 10-2, 2.81 ERA vs Miles Mikolas (Cardinals) - 5-7, 5.20 ERA

The Padres will look to Nick Pivetta (10-2) versus the Cardinals and Miles Mikolas (5-7). When Pivetta starts, his team is 12-8-0 against the spread this season. Pivetta's team is 7-4 this season when he starts and they are the moneyline favorite. The Cardinals are 9-10-0 ATS in Mikolas' 19 starts that had a set spread. The Cardinals are 6-8 in Mikolas' 14 starts this season that they were the moneyline underdog.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58%)

Padres vs Cardinals Moneyline

• San Diego is the favorite, -130 on the moneyline, while St. Louis is a +110 underdog despite being at home.

Padres vs Cardinals Spread

• The Cardinals are hosting the Padres, and are +1.5 on the runline. The Cardinals are +130 to cover the spread, and the Padres are -156.

Padres vs Cardinals Over/Under

• The over/under for Padres-Cardinals on July 25 is 8.5. The over is -114, and the under is -106.

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Padres vs Cardinals Betting Trends

• The Padres have been victorious in 30, or 60%, of the 50 contests they have been chosen as favorites in this season.
• This season San Diego has come away with a win 26 times in 42 chances when named as a favorite of at least -130 on the moneyline.
• The Padres and their opponents have gone over the total this season in 42 of their 101 opportunities.
• The Padres are 55-46-0 against the spread in their 101 games with a line set by sportsbooks this season.
• The Cardinals have put together a 26-27 record in games they were the underdog on the moneyline (winning 49.1% of those games).
• When it has played as a moneyline underdog with odds of +110 or longer, St. Louis has a record of 10-19 (34.5%).
• The Cardinals have combined with opponents to go over the total 53 times this season for a 53-43-5 record against the over/under.
• The Cardinals are 54-47-0 ATS this season.

Padres Player Leaders

• Manny Machado leads San Diego with 114 hits and a team-best slugging percentage of .494. He's batting .289 with an on-base percentage of .349.
• He is 17th in batting average, 49th in on-base percentage, and 23rd in slugging among qualified batters in the majors.
• Machado hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .316 with two doubles, a home run, three walks and three RBIs.
• Fernando Tatis Jr. has 102 hits this season and a team-best OBP of .363. He's batting .266 and slugging .446.
• He ranks 69th in batting average, 30th in on-base percentage and 65th in slugging among qualified hitters.
• Tatis has picked up at least one hit in two games in a row. In his last five games he is batting .263 with a double, a home run, two walks and an RBI.
• Luis Arraez is batting .288 with a .397 slugging percentage and 38 RBI this year.
• Arraez takes a seven-game hitting streak into this game. In his last 10 outings he is hitting .308 with three doubles, two walks and three RBIs.
• Xander Bogaerts has been key for San Diego with 96 hits, an OBP of .342 plus a slugging percentage of .381.
• Bogaerts takes a five-game hitting streak into this matchup. In his last five games he is hitting .300 with three doubles, a home run, two walks and four RBIs.

Cardinals Player Leaders

• Brendan Donovan has accumulated a .364 on-base percentage and a .433 slugging percentage, both team-best averages for the Cardinals. He's batting .296.
• Including all qualified hitters, he ranks 10th in batting average, while his on-base percentage is 29th and he is 71st in slugging.
• Alec Burleson leads his team with 91 hits. He has a batting average of .289 while slugging .460 with an on-base percentage of .340.
• Including all qualified hitters, he is 17th in batting average, 60th in on-base percentage and 50th in slugging percentage.
• Willson Contreras is hitting .262 with 27 doubles, 14 home runs and 33 walks.
• Nolan Arenado has 15 doubles, a triple, 10 home runs and 26 walks while batting .241.

Padres vs Cardinals Head to Head

• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/1/2024: 6-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/24/2023: 12-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/23/2023: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)

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