NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 8

The NFL schedule in Week 8, which includes the San Francisco 49ers squaring off against the Houston Texans, is not one to miss.

Here's everything you need to know about the betting odds for Week 8 in the NFL.

Chargers vs. Vikings

Justin Herbert will lead the Los Angeles Chargers (4-3) into their matchup versus the Minnesota Vikings (3-3) at SoFi Stadium on Thursday at 8:15 p.m. ET.

• Game Preview: Minnesota Vikings at Los Angeles Chargers
• Projected Favorite: Chargers (53.47% win probability)
• Spread: Los Angeles (-3)
• Total: 44.5 -- Over: (-112) | Under: (-108)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Los Angeles vs. Minnesota with FanDuel Sportsbook.

Ravens vs. Bears

At M&T Bank Stadium on Sunday, the Baltimore Ravens (1-5) take on the Chicago Bears (4-2).

• Game Preview: Chicago Bears at Baltimore Ravens
• Projected Favorite: Ravens (58.40% win probability)
• Spread: Baltimore (-6.5)
• Total: 50.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Chicago with FanDuel Sportsbook.

Patriots vs. Browns

Star QB Drake Maye and the New England Patriots (5-2) meet the Cleveland Browns (2-5) on Sunday at 1 p.m. ET at Gillette Stadium.

• Game Preview: Cleveland Browns at New England Patriots
• Projected Favorite: Patriots (83.01% win probability)
• Spread: New England (-7)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New England vs. Cleveland with FanDuel Sportsbook.

Panthers vs. Bills

One of the top pass-catchers in football will be on display when Dalton Kincaid and the Buffalo Bills (4-2) visit the Carolina Panthers (4-3) on Sunday, October 26, 2025.

• Game Preview: Buffalo Bills at Carolina Panthers
• Projected Favorite: Bills (62.57% win probability)
• Spread: Buffalo (-7.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Buffalo with FanDuel Sportsbook.

Falcons vs. Dolphins

On Sunday at 1 p.m. ET, a pair of excellent running backs will be on display when Bijan Robinson and the Atlanta Falcons (3-3) host De'Von Achane and the Miami Dolphins (1-6).

• Game Preview: Miami Dolphins at Atlanta Falcons
• Projected Favorite: Falcons (73.47% win probability)
• Spread: Atlanta (-7.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Atlanta vs. Miami with FanDuel Sportsbook.

Eagles vs. Giants

Jalen Hurts and the Philadelphia Eagles (5-2) will host Cam Skattebo and the New York Giants (2-5) on Sunday at 1 p.m. ET, in a matchup between two of the brightest offensive stars in football.

• Game Preview: New York Giants at Philadelphia Eagles
• Projected Favorite: Eagles (73.10% win probability)
• Spread: Philadelphia (-7)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. New York with FanDuel Sportsbook.

Bengals vs. Jets

On Sunday, Oct. 26 at 1 p.m. ET, the Cincinnati Bengals (3-4) will attempt to build upon their recent 33-31 win against the Steelers when they match up with the New York Jets (0-7) at Paycor Stadium. The Jets lost their last contest 13-6 to the Panthers.

• Game Preview: New York Jets at Cincinnati Bengals
• Projected Favorite: Bengals (66.25% win probability)
• Spread: Cincinnati (-6.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. New York with FanDuel Sportsbook.

Texans vs. 49ers

The 1 p.m. ET tilt on Oct. 26 between the San Francisco 49ers (5-2) and the Houston Texans (2-4) should be a competitive matchup, as Christian McCaffrey has been one of the league's top pass-catchers this season, and the Texans have been a top-five pass defense, ranking fifth-best in the NFL with 179.0 passing yards surrendered per game.

• Game Preview: San Francisco 49ers at Houston Texans
• Projected Favorite: Texans (64.64% win probability)
• Spread: Houston (-1.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. San Francisco with FanDuel Sportsbook.

Saints vs. Buccaneers

One of the top pass-catchers in football will be on display when Emeka Egbuka and the Tampa Bay Buccaneers (5-2) visit the New Orleans Saints (1-6) on Sunday, October 26, 2025.

• Game Preview: Tampa Bay Buccaneers at New Orleans Saints
• Projected Favorite: Buccaneers (68.44% win probability)
• Spread: Tampa Bay (-4.5)
• Total: 46.5 -- Over: (-114) | Under: (-106)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Tampa Bay with FanDuel Sportsbook.

Colts vs. Titans

Against the Tennessee Titans (1-6), who sport the 29th-ranked run defense this season, Jonathan Taylor and the Indianapolis Colts (6-1) should have success running the ball when the two teams come together on Sunday, Oct. 26 at 4:25 p.m. ET. Taylor has been one of the NFL's top rushers this season, ranking best in the league in rushing yards.

• Game Preview: Tennessee Titans at Indianapolis Colts
• Projected Favorite: Colts (90.17% win probability)
• Spread: Indianapolis (-14.5)
• Total: 46.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Tennessee with FanDuel Sportsbook.

Broncos vs. Cowboys

Star QB Dak Prescott and the Dallas Cowboys (3-3-1) meet the Denver Broncos (5-2) on Sunday at 4:25 p.m. ET, at Empower Field at Mile High.

• Game Preview: Dallas Cowboys at Denver Broncos
• Projected Favorite: Broncos (65.17% win probability)
• Spread: Denver (-3.5)
• Total: 50.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Denver vs. Dallas with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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