Iowa State vs Oklahoma State Prediction, Odds, Picks, Best Bets for Week 14 2025

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Saturday's slate in college football includes a matchup between the Iowa State Cyclones and the Oklahoma State Cowboys.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Iowa State vs Oklahoma State Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Iowa State: (-699) | Oklahoma State: (+500)
Spread: Iowa State: -14.5 (-105) | Oklahoma State: +14.5 (-115)
Total: 46.5 -- Over: (-105) | Under: (-115)

Iowa State is 5-6-0 against the spread this year.
Iowa State has won once ATS (1-1) as a 14.5-point or higher favorite this year.
This season, four of Iowa State's 11 games have hit the over.
Against the spread, Oklahoma State is 4-7-0 this year.
Oklahoma State's ATS record as 14.5-point underdogs or more is 3-5.
Oklahoma State has played 11 games this year, and five of them have gone over the total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (92.4%)

Oklahoma State is the underdog by 14.5 points against Iowa State. Oklahoma State is -105 to cover the spread, and Iowa State is -115.

Iowa State versus Oklahoma State on Nov. 29 has an over/under of 46.5 points, with the over -105 and the under -115.

Looking at the moneyline for Iowa State-Oklahoma State, Iowa State is the favorite at -699, and Oklahoma State is +500.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Iowa State	28.1	65	20.8	34	51.3	11
Oklahoma State	14.3	134	34.5	127	54.1	11

Check out even more in-depth Iowa State vs. Oklahoma State analysis on FanDuel Research.

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