Iowa State vs Kansas Prediction, Odds, Picks, Best Bets for Week 13 2025

The Iowa State Cyclones are among the college football teams in action on Saturday, versus the Kansas Jayhawks.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Iowa State vs Kansas Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-182) | Kansas: (+150)
• Spread: Iowa State: -4.5 (-105) | Kansas: +4.5 (-115)
• Total: 55.5 -- Over: (-110) | Under: (-110)

Iowa State vs Kansas Betting Trends

• Iowa State is 4-6-0 against the spread this season.
• Iowa State has won twice ATS (2-2) as a 4.5-point or bigger favorite this season.
• Out of 10 Iowa State games so far this year, four have hit the over.
• Against the spread, Kansas is 4-6-0 this season.
• Kansas has won once ATS (1-2) as a 4.5-point underdog or more this season.
• Kansas has seen five of its 10 games hit the over.

Iowa State vs Kansas Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (64.2%)

Iowa State vs Kansas Point Spread

Iowa State is favored by 4.5 points against Kansas. Iowa State is -105 to cover the spread, while Kansas is -115.

Iowa State vs Kansas Over/Under

A total of 55.5 points has been set for the Iowa State-Kansas matchup on Nov. 22, with the over available at -110 and the under at -110.

Iowa State vs Kansas Moneyline

Looking at the moneyline for Kansas-Iowa State, Kansas is the underdog at +150, and Iowa State is -182.

Iowa State vs. Kansas Points Insights

Iowa State vs. Kansas Game Info

• Game day: Saturday, November 22, 2025
• Game time: 12 p.m. ET
• TV channel: Fox Sports 1
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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Check out even more in-depth Iowa State vs. Kansas analysis on FanDuel Research.