Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 9:12 a.m.

Thursday's slate in the MLB includes a matchup between the Los Angeles Dodgers and the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (85-67) vs. San Francisco Giants (76-76)
• Date: Thursday, September 18, 2025
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: MLB Network, SportsNet LA, and NBCS-BA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-166) | SF: (+140)
• Spread: LAD: -1.5 (+130) | SF: +1.5 (-160)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 11-8, 2.66 ERA vs Logan Webb (Giants) - 14-10, 3.34 ERA

This contest's pitching matchup is set, as the Dodgers will send Yoshinobu Yamamoto (11-8) to the mound, while Logan Webb (14-10) will answer the bell for the Giants. Yamamoto and his team have a record of 12-16-0 against the spread when he starts. Yamamoto's team has a record of 14-13 this season when he starts and they are the favorite on the moneyline. When Webb starts, the Giants are 14-17-0 against the spread. The Giants won each of Webb's three starts this season that they were the moneyline underdog.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (60.1%)

Dodgers vs Giants Moneyline

• Looking at the moneyline for Giants-Dodgers, San Francisco is the underdog at +140, and Los Angeles is -166 playing at home.

Dodgers vs Giants Spread

• The Giants are at +1.5 on the runline against the Dodgers. The Giants are -160 to cover the spread, and the Dodgers are +130.

Dodgers vs Giants Over/Under

• A combined run total of 7.5 has been set for Dodgers-Giants on Sept. 18, with the over at -115 and the under at -105.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have been chosen as favorites in 133 games this year and have walked away with the win 75 times (56.4%) in those games.
• Los Angeles has a record of 44-35 in contests when sportsbooks favor them by -166 or more on the moneyline.
• Contests with the Dodgers have gone over the total set by bookmakers in 72 of 150 chances this season.
• The Dodgers have an against the spread mark of 64-86-0 in 150 games with a line this season.
• The Giants have put together a 27-33 record in games they were the underdog on the moneyline (winning 45% of those games).
• San Francisco is 1-8 (winning just 11.1% of its games) when it has played as a moneyline underdog of +140 or longer.
• The Giants have played in 151 games with a set over/under, and have combined with their opponents to go over the total 72 times (72-71-8).
• The Giants have a 71-80-0 record ATS this season (covering 47% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles with 162 hits and an OBP of .394, plus a team-best slugging percentage of .614. He's batting .282.
• He ranks 20th in batting average, second in on-base percentage, and second in slugging among all qualified hitters in baseball.
• Ohtani will look for his sixth straight game with a hit in this matchup. During his last five outings he is batting .348 with a double, three home runs, three walks and three RBIs.
• Mookie Betts is hitting .261 with 22 doubles, two triples, 19 home runs and 57 walks. He's slugging .411 with an on-base percentage of .329.
• Among qualifying hitters, his batting average ranks him 62nd, his on-base percentage 75th, and his slugging percentage 87th.
• Freddie Freeman has collected 155 base hits, an OBP of .365 and a slugging percentage of .497 this season.
• Andy Pages is batting .278 with a .320 OBP and 81 RBI for Los Angeles this season.
• Pages has hit safely in four straight games. In his last five games he is hitting .421 with two doubles, a home run, a walk and an RBI.

Giants Player Leaders

• Rafael Devers has a team-best OBP (.373), while leading the Giants in hits (145). He's batting .254 and slugging.
• Including all qualified players, he ranks 84th in batting average, while his on-base percentage is eighth and he is 39th in slugging.
• Jung Hoo Lee is hitting .262 with 30 doubles, 11 triples, eight home runs and 46 walks. He's slugging .406 with an on-base percentage of .326.
• His batting average is 59th among all qualified players, his on-base percentage ranks 78th, and he is 93rd in slugging.
• Willy Adames has 20 doubles, two triples, 28 home runs and 73 walks while batting .227.
• Matt Chapman is batting .235 with 20 doubles, two triples, 21 home runs and 66 walks.

Dodgers vs Giants Head to Head

• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/11/2025: 8-7 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/15/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/14/2025: 11-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/13/2025: 6-2 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2024: 6-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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