Diamondbacks vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 7:14 a.m.

Tuesday's slate in the MLB includes a matchup between the Arizona Diamondbacks and the San Francisco Giants.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (76-75) vs. San Francisco Giants (75-75)
• Date: Tuesday, September 16, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NBCS-BA

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-126) | SF: (+108)
• Spread: ARI: -1.5 (+168) | SF: +1.5 (-205)
• Total: 9 -- Over: (-105) | Under: (-115)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 8-8, 4.98 ERA vs TBA (Giants)

The Diamondbacks will give the ball to Eduardo Rodriguez (8-8), while the Giants' starting pitcher has not yet been announced. Rodriguez and his team have a record of 10-15-0 against the spread when he starts. Rodriguez's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 7-7.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (63.8%)

Diamondbacks vs Giants Moneyline

• Looking at the moneyline for Diamondbacks-Giants, Arizona is the favorite at -126, and San Francisco is +108 playing on the road.

Diamondbacks vs Giants Spread

• The Diamondbacks are hosting the Giants and are favored by 1.5 runs (+168 to cover) on the runline. San Francisco is -205 to cover.

Diamondbacks vs Giants Over/Under

• A total of 9 runs has been set for the Diamondbacks-Giants game on Sept. 16, with the over available at -105 and the under at -115.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have won in 43, or 52.4%, of the 82 contests they have been named as odds-on favorites in this year.
• This year Arizona has won 27 of 54 games when listed as at least -126 on the moneyline.
• Contests with the Diamondbacks have gone over the total set by oddsmakers in 73 of 147 chances this season.
• The Diamondbacks have posted a record of 74-73-0 against the spread this season.
• The Giants are 27-32 in games they were the underdog on the moneyline (winning 45.8% of those games).
• When it has played as a moneyline underdog with odds of +108 or longer, San Francisco has an 18-23 record (winning 43.9% of its games).
• In the 149 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 71 times (71-70-8).
• The Giants have covered 46.3% of their games this season, going 69-80-0 against the spread.

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona with an OBP of .391, plus a team-best slugging percentage of .462. He's batting .290 on the season.
• He ranks 15th in batting average, sixth in on-base percentage, and 45th in slugging among all qualified hitters in MLB.
• Perdomo will look for his seventh straight game with a hit in this contest. In his last 10 outings he is batting .400 with a double, a triple, three home runs, eight walks and nine RBIs.
• Corbin Carroll leads Arizona with 135 hits. He is batting .255 this season and has 76 extra-base hits. He's also slugging .542 with an on-base percentage of .337.
• He ranks 82nd in batting average, 55th in on-base percentage and seventh in slugging among qualified batters.
• Carroll has picked up a hit in two straight games. During his last five outings he is batting .235 with a double, seven walks and two RBIs.
• Ketel Marte is batting .277 with a .501 slugging percentage and 65 RBI this year.
• Gabriel Moreno has nine home runs, 37 RBI and a batting average of .289 this season.

Giants Player Leaders

• Rafael Devers has totaled 143 hits with a .375 on-base percentage, leading the Giants in both statistics. He's batting .255 and slugging .476.
• Including all the qualifying players in MLB, he ranks 82nd in batting average, ninth in on-base percentage and 33rd in slugging percentage.
• Jung Hoo Lee is hitting .264 with 30 doubles, 11 triples, eight home runs and 46 walks. He's slugging .409 with an on-base percentage of .328.
• Including all qualifying players, he ranks 49th in batting average, 76th in on-base percentage and 88th in slugging percentage.
• Willy Adames has 20 doubles, two triples, 28 home runs and 71 walks while hitting .230.
• Matt Chapman has 20 doubles, two triples, 21 home runs and 66 walks while batting .239.

Diamondbacks vs Giants Head to Head

• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2025: 10-6 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!