Creighton vs South Dakota College Basketball Prediction, Odds, Picks, Best Bets for Nov. 5

The South Dakota Coyotes (0-1) take on the Creighton Bluejays (0-0) at CHI Health Center Omaha on November 5, 2025.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Creighton vs. South Dakota Game Info and Odds

• Game day: Wednesday, November 5, 2025
• Game time: 8 p.m. ET
• TV channel: Peacock
• Location: Omaha, Nebraska
• Arena: CHI Health Center Omaha

Creighton vs. South Dakota Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Creighton win (95.5%)

Before making a bet on Wednesday's Creighton-South Dakota spread (Creighton -29.5) or total (168.5 points), read the betting trends and insights below.

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Creighton vs. South Dakota: ATS Betting Stats and Trends

• Creighton won 22 games against the spread last season, while failing to cover 14 times.
• South Dakota put together a 15-14-0 record against the spread last year.
• At home last season, the Bluejays had a worse record against the spread (11-6-0) compared to their ATS record in away games (9-2-0).
• The Coyotes were better against the spread at home (8-4-0) than on the road (6-9-0) last season.

Creighton vs. South Dakota: Moneyline Betting Stats

• Creighton went 17-4 in games it was favored on the moneyline last season (winning 81% of those games).
• The Bluejays played as a moneyline favorite of -33333 or shorter in only one game last season, which they won.
• Last season, South Dakota was the underdog 16 times and won four, or 25%, of those games.
• The Coyotes were not a bigger underdog last season than the +4000 moneyline set for this game.
• Based on this matchup's moneyline, Creighton's implied win probability is 99.7%.

Creighton vs. South Dakota Head-to-Head Comparison

• Creighton was 131st in the nation in points scored (75.5 per game) and 110th in points conceded (70) last season.
• On the glass, Creighton was 53rd in the country in rebounds (34.4 per game) last season. It was 172nd in rebounds allowed (31.1 per game).
• At 17.1 assists per game, Creighton was 13th-best in the country last year.
• In terms of turnovers, Creighton was 215th in college basketball in committing them (11.4 per game) last year. It was -4-worst in forcing them (7.4 per game).
• Because of South Dakota's defensive struggles last season, ranking -3-worst in the nation with 83.7 points allowed per game, it had to count on its offense, which ranked third-best in college basketball scoring 85.2 points per game.
• South Dakota ranked second-worst in college basketball with 35.9 rebounds allowed per game. Meanwhile, it grabbed 32.5 rebounds per game (152nd-ranked in college basketball).
• Last season South Dakota ranked 330th in college basketball in assists, dishing out 11.3 per game.
• South Dakota ranked 19th-best in the nation by averaging just 9.2 turnovers per game. In terms of forced turnovers, it ranked 62nd in college basketball (12.7 per contest).

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