Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 4:17 a.m.

The St. Louis Cardinals will face the Cincinnati Reds in MLB action on Monday.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Reds Game Info

• St. Louis Cardinals (73-77) vs. Cincinnati Reds (74-75)
• Date: Monday, September 15, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSOH

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-124) | CIN: (+106)
• Spread: STL: -1.5 (+158) | CIN: +1.5 (-192)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 7-12, 4.35 ERA vs Zack Littell (Reds) - 9-8, 3.78 ERA

The Cardinals will give the ball to Matthew Liberatore (7-12, 4.35 ERA), who is eyeing win No. 8 on the season, and the Reds will counter with Zack Littell (9-8, 3.78 ERA). Liberatore's team is 13-12-0 against the spread this season in his starts. Liberatore's team has won 35.7% of his starts when they are favored on the moneyline (5-9). The Reds have a 14-15-0 ATS record in Littell's 29 starts with a set spread. The Reds are 9-9 in Littell's 18 starts this season that they were the moneyline underdog.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.2%)

Cardinals vs Reds Moneyline

• Cincinnati is a +106 underdog on the moneyline, while St. Louis is a -124 favorite at home.

Cardinals vs Reds Spread

• The Reds are +1.5 on the spread (-192 to cover), and St. Louis is +158 to cover the runline.

Cardinals vs Reds Over/Under

• An over/under of 8.5 has been set for Cardinals-Reds on Sept. 15, with the over being -106 and the under -114.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have been favorites in 63 games this season and have come away with the win 32 times (50.8%) in those contests.
• This season St. Louis has been victorious 22 times in 42 chances when named as a favorite of at least -124 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 74 of their 144 opportunities.
• The Cardinals are 72-72-0 against the spread in their 144 games with a line set by sportsbooks this season.
• The Reds have compiled a 38-42 record in games they were the underdog on the moneyline (winning 47.5% of those games).
• Cincinnati has a 26-33 record (winning 44.1% of its games) when it has played as a moneyline underdog of +106 or longer.
• The Reds have had an over/under set by bookmakers 142 times, and have combined with opponents to go over the total in 56 of those games (56-78-8).
• The Reds have collected a 73-69-0 record ATS this season (covering 51.4% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.450) and total hits (128) this season. He's batting .281 with an on-base percentage of .332.
• Among all qualifying batters in MLB, his batting average ranks 19th, his on-base percentage ranks 65th, and he is 57th in slugging.
• Willson Contreras is hitting .255 with 30 doubles, a triple, 20 home runs and 44 walks, while slugging .444 with an on-base percentage of .342.
• Among qualified hitters, his batting average ranks him 84th, his on-base percentage 48th, and his slugging percentage 62nd.
• Contreras heads into this game looking to extend his two-game hit streak. During his last five outings he is hitting .389 with a triple, two walks and five RBIs.
• Brendan Donovan leads St. Louis with an OBP of .348 this season while batting .279 with 41 walks and 58 runs scored.
• Donovan brings a two-game hitting streak into this game. In his last five games he is hitting .300 with a double, a home run, a walk and three RBIs.
• Lars Nootbaar has 13 home runs, 47 RBI and a batting average of .240 this season.

Reds Player Leaders

• Elly De La Cruz has racked up a slugging percentage of .433 and has 154 hits, both team-high numbers for the Reds. He's batting .263 and with an on-base percentage of .331.
• Including all the qualifying hitters in the big leagues, his batting average ranks 57th, his on-base percentage is 69th, and he is 73rd in slugging.
• TJ Friedl paces his team with a .365 on-base percentage. He has a batting average of .261 while slugging .373.
• Including all qualifying hitters, he is 69th in batting average, 14th in on-base percentage and 129th in slugging percentage.
• Spencer Steer is batting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays is hitting .265 with 15 doubles, five triples, 15 home runs and 29 walks.

Cardinals vs Reds Head to Head

• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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