Cardinals vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 7:11 p.m.

The Wednesday schedule in MLB includes a matchup between the St. Louis Cardinals and the Athletics.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Athletics Game Info

• St. Louis Cardinals (69-71) vs. Athletics (64-76)
• Date: Wednesday, September 3, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and NBCS-CA

Cardinals vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | OAK: (-106)
• Spread: STL: +1.5 (-188) | OAK: -1.5 (+155)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cardinals vs Athletics Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 6-11, 4.32 ERA vs Jeffrey Springs (Athletics) - 10-9, 4.17 ERA

The Cardinals will give the ball to Matthew Liberatore (6-11, 4.32 ERA), who is eyeing win No. 7 on the season, and the Athletics will counter with Jeffrey Springs (10-9, 4.17 ERA). Liberatore and his team have a record of 12-11-0 against the spread when he starts. Liberatore's team is 4-9 this season when he starts and they are the moneyline favorite. The Athletics have gone 14-12-0 against the spread when Springs starts. The Athletics have been the underdog on the moneyline in 17 of Springs' starts this season, and they went 11-6 in those games.

Cardinals vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.2%)

Cardinals vs Athletics Moneyline

• The Cardinals vs Athletics moneyline has the Cardinals as a -110 favorite, while the Athletics are a -106 underdog on the road.

Cardinals vs Athletics Spread

• The Cardinals are hosting the Athletics and are 1.5 on the runline and -188 to cover, while Sacramento is +155 to cover the spread.

Cardinals vs Athletics Over/Under

• The over/under for Cardinals-Athletics on Sept. 3 is 8.5. The over is -115, and the under is -105.

Bet on St. Louis Cardinals vs. Athletics on FanDuel today!

Cardinals vs Athletics Betting Trends

• The Cardinals have come away with 30 wins in the 60 contests they have been listed as the favorites in this season.
• This year, the Cardinals have won 30 of 60 games when listed as at least -110 or better on the moneyline.
• The Cardinals and their opponents have hit the over in 70 of their 134 games with a total this season.
• The Cardinals are 68-66-0 against the spread in their 134 games with a line set by sportsbooks this season.
• The Athletics have compiled a 46-58 record in games they were the underdog on the moneyline (winning 44.2% of those games).
• The Athletics have a record of 44-57 when playing as a moneyline underdog with odds of -106 or longer (43.6%).
• The Athletics have combined with their opponents to go over the total 70 times this season for a 70-63-6 record against the over/under.
• The Athletics have covered 52.5% of their games this season, going 73-66-0 ATS.

Cardinals Player Leaders

• Willson Contreras is batting .249 with 30 doubles, 20 home runs and 42 walks. He has an on-base percentage of .335 and a slugging percentage of .441.
• Among all qualified batters, he ranks 98th in batting average, his on-base percentage ranks 65th, and he is 71st in slugging.
• Masyn Winn is batting .254 with 27 doubles, nine home runs and 32 walks. He's slugging .368 with an on-base percentage of .309.
• He ranks 88th in batting average, 115th in on-base percentage and 139th in slugging among qualifying hitters.
• Lars Nootbaar has collected 106 base hits, an OBP of .333 and a slugging percentage of .389 this season.
• Nootbaar brings a four-game hitting streak into this game. In his last five games he is batting .364 with a double and a triple.
• Ivan Herrera has been key for St. Louis with 88 hits, an OBP of .368 plus a slugging percentage of .450.
• Herrera takes an eight-game hitting streak into this game. In his last 10 outings he is hitting .303 with a double, three home runs, five walks and six RBIs.

Athletics Player Leaders

• Brent Rooker has a .492 slugging percentage, which paces the Athletics. He's batting .268 with an on-base percentage of .339.
• Including all the qualifying hitters in the big leagues, he ranks 51st in batting average, 57th in on-base percentage and 29th in slugging percentage.
• Tyler Soderstrom has 28 doubles, a triple, 23 home runs and 51 walks while batting .271. He's slugging .468 with an on-base percentage of .343.
• Including all qualified players, he is 42nd in batting average, 49th in on-base percentage and 45th in slugging percentage.
• Nick Kurtz is hitting .309 with 24 doubles, two triples, 27 home runs and 54 walks.
• Shea Langeliers has 106 hits to lead his team.

Cardinals vs Athletics Head to Head

• 9/2/2025: 2-1 STL (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/1/2025: 11-3 OAK (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/17/2024: 6-3 OAK (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2024: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/15/2024: 3-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/16/2023: 8-0 OAK (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/15/2023: 6-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/14/2023: 7-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +198)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!