Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 8:12 p.m.

The MLB's Tuesday schedule includes the Arizona Diamondbacks facing the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Diamondbacks vs Astros Game Info

• Arizona Diamondbacks (50-51) vs. Houston Astros (58-42)
• Date: Tuesday, July 22, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and SCHN

Diamondbacks vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-116) | HOU: (-102)
• Spread: ARI: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Diamondbacks vs Astros Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 3-6, 5.94 ERA vs Framber Valdez (Astros) - 10-4, 2.75 ERA

The Diamondbacks will call on Eduardo Rodriguez (3-6) against the Astros and Framber Valdez (10-4). Rodriguez and his team have a record of 5-10-0 against the spread when he starts. Rodriguez's team has been victorious in 36.4% of the games he's started as the moneyline favorite with a record of 4-7. The Astros have gone 9-9-0 against the spread when Valdez starts. The Astros have played while the underdog on the moneyline for three of Valdez's starts this season, and they won all of the games.

Diamondbacks vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.7%)

Diamondbacks vs Astros Moneyline

• The moneyline numbers for Diamondbacks vs. Astros reveal Arizona as the favorite (-116) and Houston as the underdog (-102) on the road.

Diamondbacks vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Astros are +168 to cover, while the Diamondbacks are -205 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Astros Over/Under

• An over/under of 8.5 has been set for Diamondbacks-Astros on July 22, with the over being -110 and the under -110.

Bet on Arizona Diamondbacks vs. Houston Astros on FanDuel today!

Diamondbacks vs Astros Betting Trends

• The Diamondbacks have been favorites in 64 games this season and have come away with the win 32 times (50%) in those contests.
• This year Arizona has won 27 of 54 games when listed as at least -116 on the moneyline.
• The Diamondbacks and their opponents have gone over in 52 of their 98 games with a total set by sportsbooks this season.
• In 98 games with a line this season, the Diamondbacks have a mark of 47-51-0 against the spread.
• The Astros have gone 19-12 in games they were the underdog on the moneyline (winning 61.3% of those games).
• Houston is 14-10 (winning 58.3% of its games) when playing as a moneyline underdog of -102 or longer.
• The Astros have played in 99 games with an over/under set, and have combined with opponents to go over the total 42 times (42-54-3).
• The Astros have a 51-48-0 record against the spread this season (covering 51.5% of the time).

Diamondbacks Player Leaders

• Geraldo Perdomo has 99 hits this season and a team-best OBP of .372. He has a .270 batting average and a slugging percentage of .417.
• Among qualified hitters in MLB, he ranks 55th in batting average, 17th in on-base percentage, and 87th in slugging.
• Eugenio Suarez leads Arizona with 93 hits. He is batting .257 this season and has 54 extra-base hits. He's also slugging .605 with an on-base percentage of .328.
• Among qualifying hitters, his batting average ranks him 84th, his on-base percentage 78th, and his slugging percentage fourth.
• Suarez heads into this matchup looking to extend his six-game hit streak. During his last 10 outings he is hitting .306 with a double, eight home runs, five walks and 12 RBIs.
• Josh Naylor has hit 11 homers with a team-high .452 SLG this season.
• Naylor heads into this matchup with two games in a row with at least one hit. During his last five outings he is hitting .263 with a double and two walks.
• Corbin Carroll is batting .250 with a .326 OBP and 49 RBI for Arizona this season.
• Carroll takes a three-game hitting streak into this game. In his last five games he is batting .261 with a double, three triples, a walk and two RBIs.

Astros Player Leaders

• Jose Altuve has a .465 slugging percentage, which leads the Astros. He's batting .278 with an on-base percentage of .337.
• Including all the qualified hitters in MLB, he is 38th in batting average, 65th in on-base percentage and 44th in slugging percentage.
• Altuve enters this matchup on a three-game hitting streak. During his last five outings he is hitting .333 with three doubles, two walks and an RBI.
• Yainer Diaz has 11 doubles, a triple, 13 home runs and 14 walks while hitting .239. He's slugging .394 with an on-base percentage of .271.
• Including all qualifying players, he ranks 122nd in batting average, 156th in on-base percentage and 110th in slugging percentage.
• Christian Walker is batting .230 with 13 doubles, a triple, 13 home runs and 25 walks.
• Cam Smith is hitting .269 with 17 doubles, two triples, seven home runs and 27 walks.

Diamondbacks vs Astros Head to Head

• 7/21/2025: 6-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2024: 12-6 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2024: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/6/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2023: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 9/30/2023: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/29/2023: 2-1 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/28/2022: 5-2 ARI (Favorite: Astros, Spread: -1.5, Total: 6, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/27/2022: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/13/2022: 3-2 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!