Yankees vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 4:18 a.m.

The MLB's Tuesday schedule includes the New York Yankees taking on the Minnesota Twins.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Yankees vs Twins Game Info

• New York Yankees (83-67) vs. Minnesota Twins (66-84)
• Date: Tuesday, September 16, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and YES

Yankees vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-162) | MIN: (+136)
• Spread: NYY: -1.5 (-108) | MIN: +1.5 (-111)
• Total: 9 -- Over: (-110) | Under: (-110)

Yankees vs Twins Probable Starting Pitchers

Probable Pitchers: Cam Schlittler (Yankees) - 3-3, 3.05 ERA vs Zebby Matthews (Twins) - 4-5, 5.06 ERA

The Yankees will call on Cam Schlittler (3-3) against the Twins and Zebby Matthews (4-5). Schlittler's team is 5-5-0 against the spread this season in his starts. Schlittler's team has won 57.1% of his starts when they are favored on the moneyline (4-3). The Twins have gone 5-9-0 ATS in Matthews' 14 starts that had a set spread. The Twins are 3-2 in Matthews' five starts this season that they were the underdog on the moneyline.

Yankees vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (56.6%)

Yankees vs Twins Moneyline

• The Yankees vs Twins moneyline has New York as a -162 favorite, while Minnesota is a +136 underdog at home.

Yankees vs Twins Spread

• The Yankees are 1.5-run road favorites on the runline against the Twins. The Yankees are -108 to cover, and the Twins are -111.

Yankees vs Twins Over/Under

• The over/under for Yankees-Twins on Sept. 16 is 9. The over is -110, and the under is -110.

Bet on New York Yankees vs. Minnesota Twins on FanDuel today!

Yankees vs Twins Betting Trends

• The Yankees have been victorious in 74, or 58.7%, of the 126 contests they have been chosen as favorites in this season.
• New York has a record of 41-25 when favored by -162 or more this year.
• The Yankees and their opponents have gone over in 72 of their 148 games with a total set by sportsbooks this season.
• The Yankees are 68-80-0 against the spread in their 148 games with a line set by sportsbooks this season.
• The Twins are 22-34 in games they were the underdog on the moneyline (winning 39.3% of those games).
• When playing as a moneyline underdog with odds of +136 or longer, Minnesota has a 6-9 record (winning 40% of its games).
• The Twins have had an over/under set by bookmakers 145 times, and have combined with opponents to go over the total in 69 of those games (69-69-7).
• The Twins have a 70-75-0 record ATS this season (covering 48.3% of the time).

Yankees Player Leaders

• Aaron Judge leads New York with 163 hits and an OBP of .449, plus a team-best slugging percentage of .677. He's batting .325.
• Among all qualifying hitters, he ranks first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger is batting .274 with 25 doubles, five triples, 28 home runs and 48 walks. He's slugging .493 with an on-base percentage of .329.
• Among all qualified, he is 33rd in batting average, 72nd in on-base percentage and 23rd in slugging percentage.
• Trent Grisham is batting .236 with a .459 slugging percentage and 64 RBI this year.
• Jazz Chisholm has 29 home runs, 75 RBI and a batting average of .242 this season.

Twins Player Leaders

• Byron Buxton has an on-base percentage of .334, a slugging percentage of .553, and has 120 hits, all club-highs for the Twins (while batting .271).
• He ranks 36th in batting average, 59th in on-base percentage and fifth in slugging percentage among all qualified batters in the majors.
• Trevor Larnach is slugging .404 to lead his team. He has a batting average of .253 with an on-base percentage of .326.
• Including all qualified hitters, his batting average puts him 87th, his on-base percentage ranks 80th, and he is 94th in slugging.
• Brooks Lee is batting .238 with 15 doubles, a triple, 15 home runs and 30 walks.
• Kody Clemens is hitting .216 with 11 doubles, three triples, 19 home runs and 26 walks.

Yankees vs Twins Head to Head

• 9/15/2025: 7-0 MIN (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/12/2025: 9-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/11/2025: 6-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/6/2024: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/5/2024: 9-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/4/2024: 5-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/16/2024: 5-0 NYY (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/15/2024: 4-0 NYY (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/14/2024: 5-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2023: 12-6 NYY (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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