White Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 4:17 a.m.

In MLB action on Tuesday, the Chicago White Sox face the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Orioles Game Info

• Chicago White Sox (57-94) vs. Baltimore Orioles (70-80)
• Date: Tuesday, September 16, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MASN2

White Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-122) | BAL: (+104)
• Spread: CHW: -1.5 (+172) | BAL: +1.5 (-210)
• Total: 7.5 -- Over: (-120) | Under: (-102)

White Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Shane Smith (White Sox) - 6-7, 3.78 ERA vs Dean Kremer (Orioles) - 9-10, 4.43 ERA

The White Sox will call on Shane Smith (6-7) versus the Orioles and Dean Kremer (9-10). Smith and his team are 14-12-0 ATS this season when he starts. Smith's team lost his only start as a favorite this season. The Orioles have a 14-13-0 record against the spread in Kremer's starts. The Orioles have a 6-9 record in Kremer's 15 starts this season when they were the underdog on the moneyline.

White Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (51.8%)

White Sox vs Orioles Moneyline

• Looking at the moneyline for Orioles-White Sox, Baltimore is the underdog at +104, and Chicago is -122 playing at home.

White Sox vs Orioles Spread

• The White Sox are hosting the Orioles and are favored by 1.5 runs on the spread. The White Sox are +172 to cover the runline, with the Orioles being -210.

White Sox vs Orioles Over/Under

• The over/under for White Sox-Orioles on Sept. 16 is 7.5. The over is -120, and the under is -102.

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White Sox vs Orioles Betting Trends

• The White Sox have split the two games they have played as odds-on favorites this season.
• These are the best odds of a victory sportsbooks have given Chicago this season, with a -122 moneyline set for this game.
• The White Sox and their opponents have hit the over in 67 of their 146 games with a total set by oddsmakers this season.
• In 146 games with a line this season, the White Sox have a mark of 83-63-0 against the spread.
• The Orioles have compiled a 38-46 record in games they were the underdog on the moneyline (winning 45.2% of those games).
• In games it has played as a moneyline underdog with odds of +104 or longer, Baltimore has gone 29-35 (45.3%).
• The Orioles have played in 147 games with a set over/under, and have combined with their opponents to go over the total 62 times (62-81-4).
• The Orioles have collected a 71-76-0 record against the spread this season (covering 48.3% of the time).

White Sox Player Leaders

• Miguel Vargas leads Chicago with an OBP of .312 this season while batting .231 with 50 walks and 71 runs scored. He has a slugging percentage of .397.
• He ranks 129th in batting average, 109th in on-base percentage, and 105th in slugging among qualifying batters in MLB.
• Andrew Benintendi is batting .240 with 16 doubles, two triples, 19 home runs and 38 walks, while slugging .424 with an on-base percentage of .304.
• Lenyn Sosa leads Chicago in slugging percentage (.426) and total hits (126) this season.
• Chase Meidroth has been key for Chicago with 109 hits, an OBP of .347 plus a slugging percentage of .344.
• Meidroth takes an 11-game hitting streak into this game. During his last 10 games he is batting .406 with a home run, five walks and two RBIs.

Orioles Player Leaders

• Gunnar Henderson has put up an on-base percentage of .346, a slugging percentage of .439, and has 143 hits, all club-highs for the Orioles (while batting .269).
• Including all the qualified hitters in the big leagues, he is 40th in batting average, 42nd in on-base percentage and 66th in slugging percentage.
• Jackson Holliday is batting .255 with 21 doubles, three triples, 17 home runs and 52 walks. He's slugging .396 with an on-base percentage of .325.
• He ranks 82nd in batting average, 83rd in on-base percentage and 106th in slugging percentage in the majors.
• Colton Cowser has 12 doubles, 15 home runs and 22 walks while hitting .202.
• Ryan Mountcastle has 18 doubles, five home runs and 14 walks while batting .256.

White Sox vs Orioles Head to Head

• 9/15/2025: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 2-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/4/2024: 8-1 CHW (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/3/2024: 9-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 9/2/2024: 13-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -460, Underdog Moneyline: +360)
• 5/25/2024: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/24/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 5/23/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +194)

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