Wake Forest vs Duke Prediction, Odds, Picks, Best Bets for Week 14 2025

The Duke Blue Devils versus the Wake Forest Demon Deacons is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Duke vs Wake Forest Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-118) | Wake Forest: (+100)
• Spread: Duke: -1.5 (-110) | Wake Forest: +1.5 (-110)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Duke vs Wake Forest Betting Trends

• Duke has five wins in 11 games against the spread this season.
• Duke owns an ATS record of 4-4 as 1.5-point or greater favorites.
• This season, eight of Duke's 11 games have hit the over.
• Wake Forest has beaten the spread eight times in 11 games.
• As 1.5-point underdogs or greater, Wake Forest is 4-2 against the spread.
• This year, six of Wake Forest's 11 games have hit the over.

Duke vs Wake Forest Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Demon Deacons win (52.9%)

Duke vs Wake Forest Point Spread

Wake Forest is a 1.5-point underdog against Duke. Wake Forest is -110 to cover the spread, and Duke is -110.

Duke vs Wake Forest Over/Under

A total of 54.5 points has been set for the Duke-Wake Forest matchup on Nov. 29, with the over available at -110 and the under at -110.

Duke vs Wake Forest Moneyline

Wake Forest is the underdog, +100 on the moneyline, while Duke is a -118 favorite.

Duke vs. Wake Forest Points Insights

Duke vs. Wake Forest Game Info

• Game day: Saturday, November 29, 2025
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: Wilmington, North Carolina
• Stadium: Brooks Field at Wallace Wade Stadium

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Check out even more in-depth Duke vs. Wake Forest analysis on FanDuel Research.